Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.42 |
| ▸ | FLT3 | P36888 | 7/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL586444 | 1.00 | KDR (0.42) | KDRFLT3MEN1KMT2ACCNE1 | |
| SCHEMBL586598 | 1.00 | KDR (0.42) | KDRFLT3MEN1KMT2ACCNE1 | |
| SCHEMBL585967 | 0.89 | PSEN1 (0.47) | KDRFLT3MEN1KMT2AAPP | |
| SCHEMBL585966 | 0.89 | PSEN1 (0.47) | KDRFLT3MEN1KMT2AAPP | |
| SCHEMBL3708734 | 0.77 | PSEN1 (0.44) | MEN1KMT2AAPPMAPT | |
| SCHEMBL3708737 | 0.77 | PSEN1 (0.44) | MEN1KMT2AAPPMAPT | |
| SCHEMBL3711358 | 0.76 | PLK4 (0.41) | MEN1KMT2ARPS6KA3 | |
| SCHEMBL3711355 | 0.76 | PLK4 (0.41) | MEN1KMT2ARPS6KA3 | |
| SCHEMBL586069 | 0.76 | NPC1 (0.35) | — | |
| SCHEMBL6522705 | 0.75 | PSEN1 (0.42) | KDRFLT3MEN1KMT2AAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417127-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | University Health Network (CA) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010115279-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2010-10-14 | — | — | WO | disclosed |