Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5863455 | 0.97 | MCHR1 (0.42) | APPKDM4EMCHR1ROCK2CYP3A4 | |
| Hydrochloric Acid SCHEMBL5863297 | 0.93 | KDM4E (0.41) | KDM4EMCHR1ALDH1A1SMN1; SMN2KMT2A | |
| Oxalic Acid SCHEMBL5863081 | 0.89 | KDM4E (0.44) | DRD3KDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL5863052 | 0.87 | KDM4E (0.45) | KDM4EMCHR1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6272024 | 0.86 | KDM4E (0.43) | DRD3KDM4EMCHR1ALDH1A1SMN1; SMN2 | |
| Oxalic Acid SCHEMBL5863422 | 0.85 | CYP3A4 (0.51) | DRD3KDM4EMCHR1ROCK2CYP3A4 | |
| SCHEMBL5863055 | 0.84 | KDM4E (0.42) | KDM4EMCHR1ALDH1A1SMN1; SMN2KMT2A | |
| Oxalic Acid SCHEMBL5863234 | 0.83 | SIGMAR1 (0.49) | KDM4EROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6252851 | 0.83 | KDM4E (0.43) | KDM4EALDH1A1SMN1; SMN2MAPTKMT2A | |
| Oxalic Acid SCHEMBL5863178 | 0.83 | KDM4E (0.43) | KDM4EALDH1A1SMN1; SMN2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132456-B2 | MCH receptor antagonists | ELI LILLY AND COMPANY (US) | 2006-11-07 | — | — | US | disclosed |
| US-20060052449-A1 | Novel mch receptor antagonists | ELI LILLY AND COMPANY | 2006-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052449-A1 | Novel mch receptor antagonists | MCHR1, MCHR2, MC1R | DRD3 134/4885APP 3982/4885KDM4E 2532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.