Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.67 |
| ▸ | MMP12 | P39900 | 2/20 | 0.62 |
| ▸ | MMP7 | P09237 | 1/20 | 0.62 |
| ▸ | MMP13 | P45452 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5248676 | 1.00 | ADAM17 (0.67) | ADAM17MMP12MMP7MMP13 | |
| SCHEMBL5866641 | 1.00 | ADAM17 (0.67) | ADAM17MMP12MMP7MMP13 | |
| SCHEMBL5866676 | 1.00 | ADAM17 (0.67) | ADAM17MMP12MMP7MMP13 | |
| Trifluoroacetic Acid SCHEMBL5866646 | 0.96 | ADAM17 (0.61) | ADAM17MMP12MMP7MMP13 | |
| Trifluoroacetic Acid SCHEMBL5866683 | 0.96 | ADAM17 (0.61) | ADAM17MMP12MMP7MMP13 | |
| Trifluoroacetic Acid SCHEMBL5866624 | 0.96 | ADAM17 (0.61) | ADAM17MMP12MMP7MMP13 | |
| Trifluoroacetic Acid SCHEMBL5866645 | 0.96 | ADAM17 (0.61) | ADAM17MMP12MMP7MMP13 | |
| SCHEMBL5262684 | 0.94 | ADAM17 (0.61) | ADAM17MMP12MMP7MMP13 | |
| SCHEMBL5262678 | 0.94 | ADAM17 (0.61) | ADAM17MMP12MMP7MMP13 | |
| SCHEMBL5866620 | 0.93 | ADAM17 (0.62) | ADAM17MMP12MMP7MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7074810-B2 | Triazolone and triazolethione derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-11 | — | — | US | claimed |
| US-20040116491-A1 | Triazolone and triazolethione derivatives as inhibitors of matrix metalloproteinases and/or TNF-alpha converting enzyme | BRISTOL-MYERS SQUIBB COMPANY | 2004-06-17 | — | — | US | claimed |