Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5866990 | 0.79 | CRHR1 (0.66) | CRHR1TP53MAPT | |
| SCHEMBL5867048 | 0.79 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL7015575 | 0.78 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL5866789 | 0.76 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL5866965 | 0.76 | CRHR1 (0.40) | CRHR1TP53MAPT | |
| SCHEMBL5866812 | 0.74 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL5866999 | 0.73 | CRHR1 (0.60) | CRHR1TP53MAPT | |
| SCHEMBL7506309 | 0.71 | — | — | |
| SCHEMBL7018361 | 0.71 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL5599986 | 0.71 | CRHR1 (0.39) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6992188-B1 | Substituted heterocyclic derivatives | PFIZER, INC. (US) | 2006-01-31 | — | — | US | disclosed |
| EP-0778277-B1 | Substituted heterocyclic derivatives as CRF antagonists | PFIZER (US) | 2003-06-25 | — | — | EP | disclosed |
| EP-0778277-A1 | Substituted heterocyclic derivatives as CRF antagonists | PFIZER INC. (US) | 1997-06-11 | — | — | EP | disclosed |