Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5842998 | 0.72 | CRHR1 (0.56) | CRHR1 | |
| SCHEMBL7020550 | 0.72 | CRHR1 (0.55) | CRHR1 | |
| SCHEMBL5866738 | 0.69 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL5844224 | 0.68 | CRHR1 (0.51) | CRHR1 | |
| SCHEMBL7016662 | 0.68 | CRHR1 (0.40) | CRHR1 | |
| SCHEMBL5843248 | 0.67 | CRHR1 (0.53) | CRHR1 | |
| SCHEMBL5844633 | 0.67 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL6799383 | 0.67 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL5844140 | 0.66 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL5875473 | 0.66 | CRHR1 (0.48) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6992188-B1 | Substituted heterocyclic derivatives | PFIZER, INC. (US) | 2006-01-31 | — | — | US | disclosed |
| EP-0778277-A1 | Substituted heterocyclic derivatives as CRF antagonists | PFIZER INC. (US) | 1997-06-11 | — | — | EP | disclosed |