Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5867002 | 0.90 | CRHR1 (0.37) | CRHR1 | |
| SCHEMBL5866765 | 0.90 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL5866787 | 0.88 | CRHR1 (0.37) | CRHR1 | |
| SCHEMBL5866996 | 0.86 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL5867073 | 0.82 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL7021243 | 0.81 | CRHR1 (0.36) | CRHR1 | |
| SCHEMBL5707852 | 0.81 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL5866848 | 0.80 | CRHR1 (0.34) | CRHR1 | |
| SCHEMBL7018137 | 0.79 | CRHR1 (0.38) | CRHR1 | |
| SCHEMBL5866815 | 0.78 | CRHR1 (0.35) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6992188-B1 | Substituted heterocyclic derivatives | PFIZER, INC. (US) | 2006-01-31 | — | — | US | disclosed |
| EP-0778277-B1 | Substituted heterocyclic derivatives as CRF antagonists | PFIZER (US) | 2003-06-25 | — | — | EP | disclosed |
| EP-0778277-A1 | Substituted heterocyclic derivatives as CRF antagonists | PFIZER INC. (US) | 1997-06-11 | — | — | EP | disclosed |