Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 19/20 | 0.48 |
| ▸ | IMPDH1 | P20839 | 12/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5867257 | 0.89 | IMPDH2 (0.58) | IMPDH2IMPDH1KDM4EALDH1A1GAA | |
| SCHEMBL5867258 | 0.88 | IMPDH2 (0.60) | IMPDH2IMPDH1 | |
| SCHEMBL5867299 | 0.87 | IMPDH2 (0.51) | IMPDH2IMPDH1KDM4EALDH1A1GAA | |
| SCHEMBL5867242 | 0.85 | IMPDH2 (0.49) | IMPDH2IMPDH1 | |
| SCHEMBL5867201 | 0.84 | IMPDH2 (0.48) | IMPDH2IMPDH1 | |
| SCHEMBL5867266 | 0.84 | IMPDH2 (0.45) | IMPDH2IMPDH1 | |
| SCHEMBL5867189 | 0.83 | IMPDH2 (0.48) | IMPDH2IMPDH1 | |
| SCHEMBL5867214 | 0.83 | IMPDH2 (0.45) | IMPDH2IMPDH1 | |
| SCHEMBL5867265 | 0.83 | IMPDH2 (0.44) | IMPDH2IMPDH1 | |
| SCHEMBL5867280 | 0.81 | IMPDH2 (0.46) | IMPDH2IMPDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060720-B2 | Inhibitors of IMPDH enzyme | BRISTOL-MYERS SQUIBB CO. (US) | 2006-06-13 | — | — | US | disclosed |