Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM6B | O15054 | 12/20 | 0.51 |
| ▸ | KDM4A | O75164 | 12/20 | 0.51 |
| ▸ | HIF1AN | Q9NWT6 | 12/20 | 0.51 |
| ▸ | KDM2A | Q9Y2K7 | 12/20 | 0.51 |
| ▸ | KDM4D | Q6B0I6 | 11/20 | 0.51 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.45 |
| ▸ | KDM5B | Q9UGL1 | 10/20 | 0.45 |
| ▸ | KDM3B | Q7LBC6 | 10/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ASPH | Q12797 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11630106 | 0.84 | HSD17B2 (0.44) | KDM6BKDM4AHIF1ANKDM2AKDM4D | |
| SCHEMBL2219244 | 0.82 | KDM6B (0.60) | KDM6BKDM4AHIF1ANKDM2AKDM4D | |
| SCHEMBL4415502 | 0.77 | KDM4E (0.61) | HSD17B2KDM4EHPGD | |
| SCHEMBL23833726 | 0.76 | PIN1 (0.46) | HSD17B2KDM4EHPGDASPHPKM | |
| SCHEMBL3586816 | 0.73 | COMT (0.68) | KDM4E | |
| SCHEMBL23900414 | 0.72 | KDM6B (0.61) | KDM6BKDM4AHIF1ANKDM2AKDM4D | |
| SCHEMBL15349327 | 0.72 | KDM6B (0.56) | KDM6BKDM4AHIF1ANKDM2AKDM4D | |
| SCHEMBL24596395 | 0.72 | HCAR2 (0.40) | HSD17B2PKMKDM5AKDM4CHCAR2 | |
| SCHEMBL22867221 | 0.70 | HSD17B2 (0.65) | HSD17B2 | |
| SCHEMBL23900635 | 0.68 | KDM6B (0.51) | KDM6BKDM4AHIF1ANKDM2AKDM4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023083210-A1 | SUBSTITUTED NAPHTHYRIDINONE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | 上海海雁医药科技有限公司 | 2023-05-19 | — | — | WO | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |