SCHEMBL5867573

SCHEMBL5867573

O=C(CNc1ccccc1)Nc1cc(C2CC2)n[nH]1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ERCC1 P07992 1/20 0.45
ERCC4 Q92889 1/20 0.45
ADORA3 P0DMS8 1/20 0.44
ADORA1 P30542 1/20 0.44
CDK2 P24941 5/20 0.42
CCNA2 P20248 3/20 0.42
CCNA1 P78396 3/20 0.42
KCNJ6 P48051 7/20 0.41
KCNJ5 P48544 7/20 0.41
KCNJ3 P48549 7/20 0.41
ALDH1A1 P00352 2/20 0.40
LMNA P02545 2/20 0.40
KMT2A Q03164 2/20 0.40
MEN1 O00255 1/20 0.40
MAPT P10636 1/20 0.40
RAB9A P51151 1/20 0.40
MGLL Q99685 1/20 0.40
CRACR2A Q9BSW2 1/20 0.39
CCNE1 P24864 2/20 0.39
CDK3 Q00526 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6387184 0.85 ADORA3 (0.39) ERCC1ERCC4ADORA3ADORA1CDK2
SCHEMBL6387194 0.85 ADORA3 (0.39) ERCC1ERCC4ADORA3ADORA1CDK2
SCHEMBL5867926 0.82 CDK2 (0.62) CDK2CCNA2CCNA1CRACR2ACCNE1
SCHEMBL5597942 0.82 TP53 (0.47) CDK2KCNJ6KCNJ5KCNJ3ALDH1A1
SCHEMBL5868034 0.80 ADORA3 (0.48) ADORA3CDK2CCNA2CCNA1LMNA
SCHEMBL5867676 0.79 SMN1; SMN2 (0.44) CDK2CCNA2CCNA1ALDH1A1KMT2A
SCHEMBL5867593 0.78 CDK2 (0.65) CDK2CCNA2CCNA1KCNJ6KCNJ5
SCHEMBL5867890 0.78 MAOB (0.52) ADORA3ADORA1CDK2CCNA2CCNA1
SCHEMBL5867891 0.78 MAOB (0.52) ADORA3ADORA1CDK2CCNA2CCNA1
SCHEMBL5867670 0.78 CCNA2 (0.59) ADORA3ADORA1CDK2CCNA2CCNA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1202733-B1 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2005-10-05 EP claimed
EP-1202733-A4 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2003-05-14 EP claimed
JP-2003507329-A 2003-02-25 JP claimed
CN-1373662-A 3(5)-amino-pyrazole derivs., process for their preparation and their use as antitumor agents PHARMACIA & UP JOHN S P A (IT) 2002-10-09 CN claimed
EP-1202733-A1 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS Pharmacia Italia S.p.A. (IT) 2002-05-08 EP claimed
WO-2001012189-A1 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA S.P.A. (IT) 2001-02-22 WO claimed
US-7034049-B1 3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents PHARMACIA ITALIA S.P.A. (IT) 2006-04-25 US disclosed
EP-1202733-B1 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2005-10-05 EP disclosed
EP-1202733-A4 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2003-05-14 EP disclosed
CN-1373662-A 3(5)-amino-pyrazole derivs., process for their preparation and their use as antitumor agents PHARMACIA & UP JOHN S P A (IT) 2002-10-09 CN disclosed
EP-1202733-A1 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS Pharmacia Italia S.p.A. (IT) 2002-05-08 EP disclosed
WO-2001012189-A1 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA S.P.A. (IT) 2001-02-22 WO disclosed