Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | STAT3 | P40763 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.58 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.54 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5869395 | 1.00 | MEN1 (0.60) | MEN1KMT2ASTAT3NPC1RAB9A | |
| SCHEMBL5869368 | 1.00 | MEN1 (0.60) | MEN1KMT2ASTAT3NPC1RAB9A | |
| SCHEMBL2752592 | 0.86 | MEN1 (0.78) | MEN1KMT2ASTAT3NPC1RAB9A | |
| SCHEMBL8249811 | 0.85 | MEN1 (0.61) | MEN1KMT2ASTAT3NPC1RAB9A | |
| SCHEMBL5869819 | 0.80 | CSNK1D (0.62) | MEN1KMT2ANPC1RAB9ACASP3 | |
| SCHEMBL5869831 | 0.80 | CSNK1D (0.62) | MEN1KMT2ANPC1RAB9ACASP3 | |
| SCHEMBL5869854 | 0.80 | CSNK1D (0.62) | MEN1KMT2ANPC1RAB9ACASP3 | |
| SCHEMBL5869363 | 0.79 | MAPK1 (0.49) | MEN1KMT2ASTAT3NPC1RAB9A | |
| SCHEMBL8250088 | 0.79 | MAPK1 (0.49) | MEN1KMT2ASTAT3NPC1RAB9A | |
| SCHEMBL7424422 | 0.79 | MEN1 (0.53) | MEN1KMT2ASTAT3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | ACE, ACE2, AGTR2 | MEN1 3996/4885KMT2A 1880/4885STAT3 2847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.