Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 3/20 | 0.75 |
| ▸ | ANPEP | P15144 | 6/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | PPID | Q08752 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | CTSL | P07711 | 1/20 | 0.60 |
| ▸ | CTSB | P07858 | 1/20 | 0.60 |
| ▸ | CTSS | P25774 | 1/20 | 0.60 |
| ▸ | CTSK | P43235 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8248836 | 1.00 | ATM (0.75) | ATMANPEPL3MBTL1MAPTPPID | |
| SCHEMBL15623786 | 0.90 | ANPEP (0.67) | ATMANPEPL3MBTL1MAPTPPID | |
| SCHEMBL4770883 | 0.87 | ANPEP (0.79) | ATMANPEPL3MBTL1MAPTALDH1A1 | |
| SCHEMBL4770866 | 0.87 | ANPEP (0.79) | ATMANPEPL3MBTL1MAPTALDH1A1 | |
| SCHEMBL24446776 | 0.87 | ANPEP (0.67) | ATMANPEPL3MBTL1MAPTPPID | |
| SCHEMBL5870605 | 0.86 | ANPEP (0.74) | ATMANPEPPSMB5POLB | |
| SCHEMBL2561481 | 0.86 | ATM (1.00) | ATMANPEPL3MBTL1MAPTALDH1A1 | |
| SCHEMBL10493865 | 0.86 | ATM (1.00) | ATMANPEPL3MBTL1MAPTALDH1A1 | |
| SCHEMBL28862820 | 0.85 | ANPEP (0.68) | ATMANPEPL3MBTL1MAPTALDH1A1 | |
| SCHEMBL28862821 | 0.85 | ANPEP (0.68) | ATMANPEPL3MBTL1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-6632830-B1 | Blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder | MILLENNIUM PHARMACEUTICALS, INC. | 2003-10-14 | — | — | US | disclosed |