Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.87 |
| ▸ | POLB | P06746 | 2/20 | 0.75 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | ANPEP | P15144 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | LCK | P06239 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10493865 | 1.00 | ATM (1.00) | ATML3MBTL1POLBMAPTANPEP | |
| SCHEMBL15623796 | 0.93 | ATM (0.87) | ATML3MBTL1POLBMAPTANPEP | |
| SCHEMBL2563776 | 0.89 | ATM (0.80) | ATML3MBTL1POLBMAPTANPEP | |
| SCHEMBL27501279 | 0.86 | POLB (0.80) | ATML3MBTL1POLBANPEPTSHR | |
| SCHEMBL5869443 | 0.86 | ATM (0.75) | ATML3MBTL1POLBMAPTANPEP | |
| SCHEMBL8248836 | 0.86 | ATM (0.75) | ATML3MBTL1POLBMAPTANPEP | |
| Hydrochloric Acid SCHEMBL7395756 | 0.86 | ATM (0.75) | ATML3MBTL1POLBMAPTANPEP | |
| SCHEMBL8022139 | 0.84 | ALDH1A1 (0.83) | ATML3MBTL1ANPEPKMT2AALDH1A1 | |
| SCHEMBL2563448 | 0.84 | ALDH1A1 (0.83) | ATML3MBTL1ANPEPKMT2AALDH1A1 | |
| SCHEMBL2039692 | 0.84 | ATM (0.72) | ATML3MBTL1POLBMAPTANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560949-B1 | TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASE LSD1 AND/OR LSD2 | UNIVERSIT DEGLI STUDI DI ROMA LA SAPIENZA (IT) | 2015-12-02 | — | — | EP | disclosed |
| US-8765820-B2 | Tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and/or LSD2 | Universita Degli Studi Di Roma “La Sapienza” (IT) | 2014-07-01 | — | — | US | disclosed |
| US-8765820-B2 | Tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and/or LSD2 | Universita Degli Studi Di Roma “La Sapienza” (IT) | 2014-07-01 | — | — | US | disclosed |
| EP-2560949-A1 | TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASE LSD1 AND/OR LSD2 | Università degli Studi di Roma "La Sapienza" (IT) | 2013-02-27 | — | — | EP | disclosed |
| US-20130035377-A1 | TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASES LSD1 AND/OR LSD2 | UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (IT) | 2013-02-07 | — | — | US | disclosed |
| WO-2011131576-A1 | TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASE LSD1 AND/OR LSD2 | UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (IT) | 2011-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130035377-A1 | TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASES LSD1 AND/OR LSD2 | KDM1B, KDM2A, KDM3A | ATM 3894/4885L3MBTL1 176/4885POLB 1952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.