Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BIRC2 | Q13490 | 1/20 | 0.57 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.51 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.51 |
| ▸ | MMP3 | P08254 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 2/20 | 0.49 |
| ▸ | ANPEP | P15144 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5869570 | 1.00 | BIRC2 (0.57) | BIRC2TAS1R3TAS1R1MMP3ALDH1A1 | |
| SCHEMBL5869576 | 1.00 | BIRC2 (0.57) | BIRC2TAS1R3TAS1R1MMP3ALDH1A1 | |
| SCHEMBL17452196 | 0.87 | BIRC2 (0.59) | BIRC2TAS1R3TAS1R1MMP3ALDH1A1 | |
| SCHEMBL10949321 | 0.87 | BIRC2 (0.65) | BIRC2ALDH1A1THRBCYP2C9CYP2C19 | |
| SCHEMBL24356018 | 0.86 | BIRC2 (0.58) | BIRC2TAS1R3TAS1R1MMP3ALDH1A1 | |
| SCHEMBL7022794 | 0.84 | SMN1; SMN2 (0.48) | BIRC2ALDH1A1THRBCYP2C9CYP2C19 | |
| SCHEMBL11205478 | 0.82 | BIRC2 (0.59) | BIRC2ALDH1A1THRBCYP2C9CYP2C19 | |
| SCHEMBL5870502 | 0.81 | BIRC2 (0.53) | BIRC2TAS1R3TAS1R1MMP3ALDH1A1 | |
| SCHEMBL5870510 | 0.81 | BIRC2 (0.53) | BIRC2TAS1R3TAS1R1MMP3ALDH1A1 | |
| SCHEMBL5870505 | 0.81 | BIRC2 (0.53) | BIRC2TAS1R3TAS1R1MMP3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | ACE, ACE2, AGTR2 | BIRC2 2483/4885TAS1R3 4635/4885TAS1R1 4625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.