Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.56 |
| ▸ | MME | P08473 | 1/20 | 0.51 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPR3 | P17342 | 1/20 | 0.46 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.46 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8248824 | 1.00 | REN (0.56) | RENMMECTSSCTSKPOLB | |
| SCHEMBL8248827 | 1.00 | REN (0.56) | RENMMECTSSCTSKPOLB | |
| SCHEMBL9443008 | 0.95 | REN (0.58) | RENMMECTSSCTSKPOLB | |
| SCHEMBL7380184 | 0.95 | REN (0.58) | RENMMECTSSCTSKPOLB | |
| SCHEMBL7380187 | 0.95 | REN (0.58) | RENMMECTSSCTSKPOLB | |
| SCHEMBL10707175 | 0.91 | REN (0.57) | RENCTSSCTSKPOLBMAPT | |
| SCHEMBL10707172 | 0.91 | REN (0.57) | RENCTSSCTSKPOLBMAPT | |
| SCHEMBL7329599 | 0.88 | REN (0.57) | RENCTSSCTSKPOLBMAPT | |
| SCHEMBL9442911 | 0.88 | REN (0.57) | RENCTSSCTSKPOLBMAPT | |
| SCHEMBL7387244 | 0.88 | REN (0.57) | RENCTSSCTSKPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-6632830-B1 | Blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder | MILLENNIUM PHARMACEUTICALS, INC. | 2003-10-14 | — | — | US | disclosed |