Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.60 |
| ▸ | ACE | P12821 | 4/20 | 0.60 |
| ▸ | GRN | P28799 | 5/20 | 0.48 |
| ▸ | SORT1 | Q99523 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NTSR1 | P30989 | 3/20 | 0.35 |
| ▸ | MMP1 | P03956 | 3/20 | 0.35 |
| ▸ | MMP9 | P14780 | 3/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5869535 | 1.00 | ACE2 (0.60) | ACE2ACEGRNSORT1ALDH1A1 | |
| SCHEMBL5869750 | 1.00 | ACE2 (0.60) | ACE2ACEGRNSORT1ALDH1A1 | |
| SCHEMBL22491218 | 0.94 | ACE2 (0.54) | ACE2ACEGRNSORT1ALDH1A1 | |
| SCHEMBL5869641 | 0.89 | ACE2 (0.48) | ACE2ACEGRNSORT1ALDH1A1 | |
| SCHEMBL5869646 | 0.89 | ACE2 (0.48) | ACE2ACEGRNSORT1ALDH1A1 | |
| SCHEMBL5869636 | 0.89 | ACE2 (0.48) | ACE2ACEGRNSORT1ALDH1A1 | |
| SCHEMBL22491222 | 0.87 | ACE2 (0.48) | ACE2ACEGRNSORT1ALDH1A1 | |
| SCHEMBL5869775 | 0.87 | ACE (0.47) | ACE2ACENTSR1MMP1MMP9 | |
| SCHEMBL5869803 | 0.87 | ACE (0.47) | ACE2ACENTSR1MMP1MMP9 | |
| SCHEMBL5869807 | 0.87 | ACE (0.47) | ACE2ACENTSR1MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | ACE, ACE2, AGTR2 | ACE2 2/4885ACE 1/4885GRN 3026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.