SCHEMBL586993

SCHEMBL586993

O=C1NCC=CCN1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CDA P32320 11/20 1.00
MAPT P10636 1/20 0.47
SLC28A1 O00337 1/20 0.46
SLC28A2 O43868 1/20 0.46
SLC29A1 Q99808 1/20 0.46
SLC28A3 Q9HAS3 1/20 0.46
PYGM P11217 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL583301 1.00 CDA (1.00) CDAMAPTSLC28A1SLC28A2SLC29A1
SCHEMBL587033 1.00 CDA (1.00) CDAMAPTSLC28A1SLC28A2SLC29A1
SCHEMBL11312120 1.00 CDA (1.00) CDAMAPTSLC28A1SLC28A2SLC29A1
SCHEMBL13030839 0.88 CDA (1.00) CDAMAPTSLC28A1SLC28A2SLC29A1
SCHEMBL13030840 0.88 CDA (1.00) CDAMAPTSLC28A1SLC28A2SLC29A1
SCHEMBL18601821 0.88 CDA (1.00) CDAMAPTSLC28A1SLC28A2SLC29A1
SCHEMBL23240639 0.80 CDA (0.67) CDAMAPTSLC28A1SLC28A2SLC29A1
SCHEMBL6675748 0.80 CDA (0.67) CDAMAPTSLC28A1SLC28A2SLC29A1
SCHEMBL3498860 0.80 CDA (0.67) CDAMAPTSLC28A1SLC28A2SLC29A1
SCHEMBL27055218 0.80 CDA (0.67) CDAMAPTSLC28A1SLC28A2SLC29A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2416780-B1 COMBINATION OF DECITABINE WITH CYTIDINE DEAMINASE INHIBITOR AND USE THEREOF IN THE TREATMENT OF CANCER OTSUKA PHARMA CO LTD (JP) 2017-03-08 EP disclosed
EP-2416780-B1 COMBINATION OF DECITABINE WITH CYTIDINE DEAMINASE INHIBITOR AND USE THEREOF IN THE TREATMENT OF CANCER OTSUKA PHARMA CO LTD (JP) 2017-03-08 EP disclosed
EP-2416781-B1 COMBINATION OF CYTIDINE-BASED ANTINEOPLASTIC DRUGS WITH CYTIDINE DEAMINASE INHIBITOR AND USE THEREOF IN THE TREATMENT OF CANCER OTSUKA PHARMA CO LTD (JP) 2017-03-08 EP disclosed
EP-2416781-B1 COMBINATION OF CYTIDINE-BASED ANTINEOPLASTIC DRUGS WITH CYTIDINE DEAMINASE INHIBITOR AND USE THEREOF IN THE TREATMENT OF CANCER OTSUKA PHARMA CO LTD (JP) 2017-03-08 EP disclosed
EP-2417146-B1 (2'-DEOXY-RIBOFURANOSYL)-1,3,4,7-TETRAHYDRO-(1,3)DIAZEPIN-2-ONE DERIVATIVES FOR TREATING CANCER OTSUKA PHARMA CO LTD (JP) 2016-07-13 EP disclosed
EP-2417146-B1 (2'-DEOXY-RIBOFURANOSYL)-1,3,4,7-TETRAHYDRO-(1,3)DIAZEPIN-2-ONE DERIVATIVES FOR TREATING CANCER OTSUKA PHARMA CO LTD (JP) 2016-07-13 EP disclosed
US-9040501-B2 Compositions and methods for treating cancer OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2015-05-26 US disclosed
US-9040501-B2 Compositions and methods for treating cancer OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2015-05-26 US disclosed
US-9040501-B2 Compositions and methods for treating cancer OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2015-05-26 US disclosed
US-20140221305-A1 Compositions and Methods for Treating Cancer EISAI INC. (US) 2014-08-07 US disclosed
WO-2010118010-A1 COMBINATION OF DECITABINE WITH CYTIDINE DEAMINASE INHIBITOR AND USE THEREOF IN THE TREATMENT OF CANCER EISAI INC. (US) 2010-10-14 WO disclosed
WO-2010118010-A1 COMBINATION OF DECITABINE WITH CYTIDINE DEAMINASE INHIBITOR AND USE THEREOF IN THE TREATMENT OF CANCER EISAI INC. (US) 2010-10-14 WO disclosed
WO-2010118006-A1 (2 ' -DEOXY-RIBOFURANOSYL) -1,3,4, 7-TETRAHYDRO- (1,3) IAZEPIN-2-0NE DERIVATIVES FOR TREATING CANCER EISAI INC. (US) 2010-10-14 WO disclosed
WO-2010118006-A1 (2 ' -DEOXY-RIBOFURANOSYL) -1,3,4, 7-TETRAHYDRO- (1,3) IAZEPIN-2-0NE DERIVATIVES FOR TREATING CANCER EISAI INC. (US) 2010-10-14 WO disclosed
WO-2010118013-A1 COMBINATION OF CYTIDINE-BASED ANTINEOPLASTIC DRUGS WITH CYTIDINE DEAMINASE INHIBITOR AND USE THEREOF IN THE TREATMENT OF CANCER EISAI INC. (US) 2010-10-14 WO disclosed
WO-2010118013-A1 COMBINATION OF CYTIDINE-BASED ANTINEOPLASTIC DRUGS WITH CYTIDINE DEAMINASE INHIBITOR AND USE THEREOF IN THE TREATMENT OF CANCER EISAI INC. (US) 2010-10-14 WO disclosed
EP-0065324-A1 1,3-Diazepine compounds THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce (US) 1982-11-24 EP disclosed
EP-0034424-A2 Seven-membered ring compounds as inhibitors of cytidine deaminase THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce (US) 1981-08-26 EP disclosed
WO-1981002164-A1 SEVEN-MEMBERED RING COMPOUNDS AS INHIBITORS OF CYTIDINE DEAMINASE US COMMERCE (US) 1981-08-06 WO disclosed
US-4275057-A CANCER AND ANTITUMOR DRUG RESEARCH THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) 1981-06-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140221305-A1 Compositions and Methods for Treating Cancer RNASE1, UNG, HCCS CDA 537/4885MAPT 4204/4885SLC28A1 3363/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.