Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL586902 | 0.87 | CHRM1 (0.38) | CHRM1ALDH1A1TDP1HSD17B10L3MBTL1 | |
| SCHEMBL3074935 | 0.83 | GAA (0.36) | CHRM1ALDH1A1L3MBTL1MAPTHTT | |
| SCHEMBL581244 | 0.83 | GAA (0.36) | CHRM1ALDH1A1L3MBTL1MAPTHTT | |
| SCHEMBL580903 | 0.83 | GAA (0.36) | CHRM1ALDH1A1L3MBTL1MAPTHTT | |
| SCHEMBL3085316 | 0.82 | CHRM1 (0.38) | CHRM1ALDH1A1HCRTR2TDP1SMN1; SMN2 | |
| SCHEMBL3069035 | 0.82 | CHRM1 (0.38) | CHRM1ALDH1A1HCRTR2TDP1SMN1; SMN2 | |
| SCHEMBL581176 | 0.82 | CHRM1 (0.38) | CHRM1ALDH1A1HCRTR2TDP1SMN1; SMN2 | |
| SCHEMBL582086 | 0.76 | PPARG (0.40) | CHRM1ALDH1A1TDP1MAPTMEN1 | |
| SCHEMBL3075222 | 0.76 | PPARG (0.40) | CHRM1ALDH1A1TDP1MAPTMEN1 | |
| SCHEMBL3075705 | 0.76 | PPARG (0.40) | CHRM1ALDH1A1TDP1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |