Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CCL5 | P13501 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL587020 | 0.87 | CHRM1 (0.37) | CHRM1ALDH1A1TDP1MAPTKDM4E | |
| SCHEMBL582160 | 0.74 | KMT2A (0.41) | CHRM1ALDH1A1TDP1KDM4EKMT2A | |
| SCHEMBL582882 | 0.73 | ALDH1A1 (0.44) | ALDH1A1TDP1KDM4EKMT2ACHRM3 | |
| SCHEMBL582364 | 0.73 | HTR2A (0.41) | CHRM1ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL3085316 | 0.72 | CHRM1 (0.38) | CHRM1ALDH1A1TDP1MAPTKDM4E | |
| SCHEMBL581176 | 0.72 | CHRM1 (0.38) | CHRM1ALDH1A1TDP1MAPTKDM4E | |
| SCHEMBL3069035 | 0.72 | CHRM1 (0.38) | CHRM1ALDH1A1TDP1MAPTKDM4E | |
| SCHEMBL586931 | 0.72 | KDM4E (0.39) | ALDH1A1TDP1MAPTKDM4EKMT2A | |
| SCHEMBL580903 | 0.70 | GAA (0.36) | CHRM1ALDH1A1MAPTKDM4EL3MBTL1 | |
| SCHEMBL581244 | 0.70 | GAA (0.36) | CHRM1ALDH1A1MAPTKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |