Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL586962 | 0.96 | ALDH1A1 (0.42) | ALDH1A1NPSR1MAPTHPGDHSD17B10 | |
| SCHEMBL581906 | 0.96 | NOTUM (0.41) | ALDH1A1NPSR1MAPTHPGDHSD17B10 | |
| SCHEMBL587414 | 0.84 | SMN1; SMN2 (0.42) | ALDH1A1NPSR1MAPTHPGDHSD17B10 | |
| SCHEMBL580897 | 0.84 | SMN1; SMN2 (0.39) | ALDH1A1NPSR1MAPTHPGDHSD17B10 | |
| SCHEMBL580959 | 0.83 | NOTUM (0.45) | ALDH1A1KMT2ANOTUMPKMKDM4E | |
| SCHEMBL586492 | 0.83 | DPP4 (0.49) | ALDH1A1NPSR1MAPTHPGDHSD17B10 | |
| SCHEMBL582105 | 0.83 | ALDH1A1 (0.45) | ALDH1A1NOTUMPKMDPP4DPP8 | |
| SCHEMBL581500 | 0.83 | DPP4 (0.43) | ALDH1A1NOTUMSMN1; SMN2DPP4DPP8 | |
| SCHEMBL586861 | 0.83 | ALDH1A1 (0.47) | ALDH1A1NPSR1MAPTHPGDHSD17B10 | |
| SCHEMBL587229 | 0.82 | KDM4E (0.48) | ALDH1A1NPSR1MAPTHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |