Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 4/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872305 | 1.00 | CYP2D6 (0.47) | CYP2D6ALDH1A1CYP2C19HSD17B10KDM4E | |
| SCHEMBL5872314 | 1.00 | CYP2D6 (0.47) | CYP2D6ALDH1A1CYP2C19HSD17B10KDM4E | |
| SCHEMBL7786353 | 1.00 | CYP2D6 (0.47) | CYP2D6ALDH1A1CYP2C19HSD17B10KDM4E | |
| SCHEMBL1131649 | 0.80 | KCNA5 (0.49) | CYP2D6ALDH1A1CYP2C19HSD17B10KDM4E | |
| SCHEMBL607719 | 0.80 | KCNA5 (0.49) | CYP2D6ALDH1A1CYP2C19HSD17B10KDM4E | |
| SCHEMBL1131651 | 0.80 | KCNA5 (0.49) | CYP2D6ALDH1A1CYP2C19HSD17B10KDM4E | |
| SCHEMBL8620148 | 0.79 | KCNA5 (0.47) | CYP2D6ALDH1A1CYP2C19HSD17B10KDM4E | |
| SCHEMBL7859912 | 0.79 | LMNA (0.61) | CYP2D6ALDH1A1CYP2C19HSD17B10KDM4E | |
| Hydrochloric Acid SCHEMBL6543858 | 0.79 | KCNA5 (0.47) | CYP2D6ALDH1A1CYP2C19HSD17B10KDM4E | |
| Hydrochloric Acid SCHEMBL6543863 | 0.79 | KCNA5 (0.47) | CYP2D6ALDH1A1CYP2C19HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9637457-B2 | Process for the stereoselective preparation of a pyrazole-carboxamide | SYNGENTA PARTICIPATIONS AG (CH) | 2017-05-02 | — | — | US | disclosed |
| US-9637457-B2 | Process for the stereoselective preparation of a pyrazole-carboxamide | SYNGENTA PARTICIPATIONS AG (CH) | 2017-05-02 | — | — | US | disclosed |
| US-20160108001-A1 | PROCESS FOR THE STEREOSELECTIVE PREPARATION OF A PYRAZOLE-CARBOXAMIDE | SYNGENTA PARTICIPATIONS AG (CH) | 2016-04-21 | — | — | US | disclosed |
| US-20160108001-A1 | PROCESS FOR THE STEREOSELECTIVE PREPARATION OF A PYRAZOLE-CARBOXAMIDE | SYNGENTA PARTICIPATIONS AG (CH) | 2016-04-21 | — | — | US | disclosed |
| WO-2014206855-A1 | PROCESS FOR THE STEREOSELECTIVE PREPARATION OF A PYRAZOLE-CARBOXAMIDE | SYNGENTA PARTICIPATIONS AG (CH) | 2014-12-31 | — | — | WO | disclosed |
| US-7126028-B1 | Process for preparing chiral compounds | THE UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWS (GB) | 2006-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160108001-A1 | PROCESS FOR THE STEREOSELECTIVE PREPARATION OF A PYRAZOLE-CARBOXAMIDE | CYP3A4, CYP2C9, CYP2C19 | CYP2D6 50/4885ALDH1A1 366/4885CYP2C19 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.