Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | PPARG | P37231 | 7/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | PYGL | P06737 | 1/20 | 0.33 |
| ▸ | PYGM | P11217 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048516 | 0.84 | PPARG (0.46) | GFERMCL1KDM4EALDH1A1HPGD | |
| SCHEMBL5117903 | 0.84 | PPARG (0.39) | GFERMCL1KDM4EALDH1A1HPGD | |
| SCHEMBL4049554 | 0.83 | MCL1 (0.44) | GFERMCL1KDM4EALDH1A1HPGD | |
| SCHEMBL5124452 | 0.83 | PPARG (0.40) | GFERMCL1KDM4EALDH1A1HPGD | |
| SCHEMBL5125532 | 0.83 | PPARG (0.48) | GFERMCL1KDM4EALDH1A1HPGD | |
| SCHEMBL5123585 | 0.82 | MCL1 (0.40) | GFERMCL1KDM4EALDH1A1HPGD | |
| SCHEMBL14276282 | 0.81 | GFER (0.39) | GFERMCL1KDM4EALDH1A1HPGD | |
| SCHEMBL5111493 | 0.81 | BRAF (0.51) | PYGLPYGM | |
| SCHEMBL5119451 | 0.80 | RAF1 (0.35) | GFERMCL1KDM4EALDH1A1HPGD | |
| SCHEMBL5125400 | 0.80 | PPARG (0.39) | GFERMCL1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7078419-B2 | N-aryl-7-(pyridin-4yl-methyl-, oxy-, thio-or amino-)indole-2-carbonamide derivatives, e.g., 7-(2,6-Dimethyl-pyridin-4-yloxy)-1H-indole-2-carboxylic acid (5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenyl)-amide; treating chronic inflammatory diseases and anticoagulant or fibrinolytic therapy | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-07-18 | — | — | US | claimed |