Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 2/20 | 0.35 |
| ▸ | BRAF | P15056 | 2/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | PYGL | P06737 | 4/20 | 0.35 |
| ▸ | PYGM | P11217 | 4/20 | 0.35 |
| ▸ | PPARG | P37231 | 7/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5111493 | 0.81 | BRAF (0.51) | RAF1BRAFPYGLPYGM | |
| SCHEMBL5125532 | 0.80 | PPARG (0.48) | GFERPYGLPYGMPPARGMCL1 | |
| SCHEMBL5872500 | 0.80 | GFER (0.40) | GFERPYGLPYGMPPARGMCL1 | |
| SCHEMBL5119436 | 0.80 | PYGL (0.41) | RAF1BRAFPYGLPYGMKDM4E | |
| SCHEMBL5117903 | 0.80 | PPARG (0.39) | GFERPPARGMCL1SRD5A2P2RX3 | |
| SCHEMBL14276263 | 0.79 | P2RX3 (0.39) | PYGLPYGMPPARGP2RX3KDM4E | |
| SCHEMBL5124452 | 0.78 | PPARG (0.40) | GFERPPARGMCL1SRD5A2P2RX3 | |
| SCHEMBL4048516 | 0.78 | PPARG (0.46) | BRAFGFERPYGLPYGMPPARG | |
| SCHEMBL5118388 | 0.77 | HRH3 (0.41) | — | |
| SCHEMBL4049554 | 0.76 | MCL1 (0.44) | RAF1GFERPPARGMCL1SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335657-B2 | Cytokine inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | claimed |