Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 12/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 12/20 | 0.46 |
| ▸ | KCNE1 | P15382 | 6/20 | 0.46 |
| ▸ | KCNQ1 | P51787 | 6/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.39 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.39 |
| ▸ | OXTR | P30559 | 1/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872778 | 0.96 | KCNQ3 (0.46) | KCNQ3KCNQ2KCNE1KCNQ1MAP2K1 | |
| SCHEMBL5873059 | 0.84 | SORT1 (0.47) | MAP2K1MEN1KMT2ATDP1IDO1 | |
| SCHEMBL5872850 | 0.81 | MAP2K1 (0.56) | MAP2K1MEN1KMT2ATDP1IDO1 | |
| SCHEMBL5872916 | 0.80 | NPC1 (0.49) | MEN1KMT2ATDP1IDO1 | |
| SCHEMBL5873057 | 0.80 | SORT1 (0.47) | MAP2K1MEN1KMT2ATDP1IDO1 | |
| SCHEMBL5873051 | 0.80 | KMT2A (0.47) | MAP2K1MEN1KMT2ATDP1IDO1 | |
| SCHEMBL5872861 | 0.80 | MEN1 (0.53) | MAP2K1MEN1KMT2ATDP1IDO1 | |
| SCHEMBL5873019 | 0.78 | MAPT (0.47) | MEN1KMT2ATDP1 | |
| SCHEMBL5872912 | 0.77 | NPC1 (0.49) | MEN1KMT2ATDP1IDO1 | |
| SCHEMBL5873050 | 0.77 | AURKA (0.45) | MAP2K1MEN1KMT2ATDP1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001905-B2 | Substituted diarylamines as MEK inhibitors | WARNER-LAMBERT COMPANY (US) | 2006-02-21 | — | — | US | disclosed |
| US-20030225076-A1 | 5-Amide substituted diarylamines as mex inhibitors | BIWERSI CATHLIN (US) | 2003-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225076-A1 | 5-Amide substituted diarylamines as mex inhibitors | NRAS, MAPK6, MAPK12 | KCNQ3 3233/4885KCNQ2 2538/4885KCNE1 1465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.