Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 4/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | GPR6 | P46095 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MYC | P01106 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872767 | 0.90 | MAP2K2 (0.38) | AURKATNFRSF1AKDRMAP3K9MAP2K2 | |
| SCHEMBL5872893 | 0.83 | KMT2A (0.40) | MAP2K2MAP2K1ALDH1A1MEN1KMT2A | |
| SCHEMBL5872799 | 0.82 | MAP2K1 (0.49) | MAP2K2MAP2K1MEN1KMT2ATDP1 | |
| SCHEMBL5872950 | 0.81 | MAP2K1 (0.46) | AURKATNFRSF1AKDRMAP3K9MAP2K2 | |
| SCHEMBL5872955 | 0.80 | MAP2K1 (0.42) | MAP2K2MAP2K1ALDH1A1MEN1KMT2A | |
| SCHEMBL5872944 | 0.80 | MAP2K1 (0.43) | AURKATNFRSF1AKDRMAP3K9MAP2K2 | |
| SCHEMBL5872969 | 0.80 | MAP2K1 (0.40) | AURKATNFRSF1AKDRMAP3K9MAP2K2 | |
| SCHEMBL5872805 | 0.79 | ALDH1A1 (0.51) | ALDH1A1MEN1KMT2AKDM4ELMNA | |
| SCHEMBL5872758 | 0.79 | MAP2K1 (0.47) | AURKATNFRSF1AKDRMAP3K9MAP2K2 | |
| SCHEMBL5873116 | 0.79 | MAP2K1 (0.48) | MAP2K2MAP2K1MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001905-B2 | Substituted diarylamines as MEK inhibitors | WARNER-LAMBERT COMPANY (US) | 2006-02-21 | — | — | US | disclosed |