Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.39 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872815 | 0.96 | SMN1; SMN2 (0.44) | SMN1; SMN2MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL5872774 | 0.85 | MEN1 (0.43) | MEN1KMT2ATDP1MAP2K2MAP2K1 | |
| SCHEMBL5872772 | 0.82 | MEN1 (0.42) | MEN1KMT2ATDP1MAP2K2MAP2K1 | |
| SCHEMBL5872850 | 0.78 | MAP2K1 (0.56) | SMN1; SMN2MEN1KMT2ATDP1MAP2K2 | |
| SCHEMBL5872902 | 0.78 | MAP2K1 (0.49) | MEN1KMT2ATDP1MAP2K2MAP2K1 | |
| SCHEMBL5872840 | 0.78 | USP2 (0.50) | SMN1; SMN2MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL5872861 | 0.78 | MEN1 (0.53) | SMN1; SMN2MEN1KMT2ATDP1MAP2K2 | |
| SCHEMBL5872818 | 0.77 | MEN1 (0.50) | SMN1; SMN2MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL12403932 | 0.76 | ALDH1A1 (0.49) | SMN1; SMN2MEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL6261773 | 0.76 | HDAC3 (0.46) | MEN1KMT2ATDP1ALDH1A1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001905-B2 | Substituted diarylamines as MEK inhibitors | WARNER-LAMBERT COMPANY (US) | 2006-02-21 | — | — | US | disclosed |
| US-20030225076-A1 | 5-Amide substituted diarylamines as mex inhibitors | BIWERSI CATHLIN (US) | 2003-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225076-A1 | 5-Amide substituted diarylamines as mex inhibitors | NRAS, MAPK6, MAPK12 | SMN1; SMN2 3308/4885MEN1 2841/4885KMT2A 636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.