Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | METAP2 | P50579 | 3/20 | 0.45 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.40 |
| ▸ | EED | O75530 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
| ▸ | POLR1A | O95602 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872926 | 0.97 | MEN1 (0.47) | MEN1KMT2ATDP1METAP2ACKR3 | |
| SCHEMBL5872807 | 0.81 | MEN1 (0.48) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5872796 | 0.81 | KMT2A (0.51) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5872846 | 0.80 | KMT2A (0.49) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5872920 | 0.80 | RAB9A (0.49) | MEN1KMT2ATDP1 | |
| SCHEMBL5872762 | 0.78 | MEN1 (0.53) | MEN1KMT2ATDP1 | |
| SCHEMBL5872804 | 0.78 | BCL3 (0.47) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5872850 | 0.77 | MAP2K1 (0.56) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5872844 | 0.77 | KMT2A (0.47) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5872795 | 0.77 | KMT2A (0.49) | MEN1KMT2ATDP1MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001905-B2 | Substituted diarylamines as MEK inhibitors | WARNER-LAMBERT COMPANY (US) | 2006-02-21 | — | — | US | disclosed |