Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.53 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.48 |
| ▸ | PHGDH | O43175 | 1/20 | 0.44 |
| ▸ | WNT1 | P04628 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5769229 | 0.91 | MAPK8 (0.56) | HPGDNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5773440 | 0.80 | MAPK1 (0.53) | HPGDNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5769397 | 0.80 | MAP2K4 (0.67) | HPGDNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL7504405 | 0.76 | NPC1 (0.82) | HPGDNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5777148 | 0.75 | KDM4E (0.63) | HPGDNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5772080 | 0.75 | KDM4E (0.60) | HPGDNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5778728 | 0.74 | MEN1 (0.47) | HPGDNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5770666 | 0.74 | MAPK10 (0.53) | HPGDNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL5771544 | 0.73 | CYP19A1 (0.51) | HPGDNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5772284 | 0.73 | KDM4E (0.46) | HPGDNPC1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984652-B2 | Gyrase inhibitors | WARNER-LAMBERT COMPANY LLC (US) | 2006-01-10 | — | — | US | disclosed |
| US-20050250823-A1 | Gyrase inhibitors | YAGER KRAIG | 2005-11-10 | — | — | US | disclosed |
| US-20050054697-A1 | Gyrase inhibitors | PFIZER INC. | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054697-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | HPGD 378/4885NPC1 3508/4885RAB9A 3514/4885 |
| US-20050250823-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | HPGD 378/4885NPC1 3508/4885RAB9A 3514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.