Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.55 |
| ▸ | WNT1 | P04628 | 3/20 | 0.39 |
| ▸ | PIM1 | P11309 | 6/20 | 0.37 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872781 | 0.95 | DYRK1A (0.50) | DYRK1AWNT1PIM1 | |
| SCHEMBL5775521 | 0.91 | DYRK1A (0.55) | DYRK1AWNT1PIM1GSK3BADORA2A | |
| SCHEMBL5872806 | 0.86 | DYRK1A (0.41) | DYRK1AWNT1PIM1GSK3BMAP2K4 | |
| SCHEMBL5873102 | 0.86 | DYRK1A (0.49) | DYRK1AWNT1PIM1 | |
| SCHEMBL5770848 | 0.86 | DYRK1A (0.41) | DYRK1AWNT1PIM1GSK3BADORA1 | |
| SCHEMBL5769525 | 0.85 | PIM1 (0.41) | DYRK1AWNT1PIM1TLR8TLR7 | |
| SCHEMBL5873198 | 0.85 | KDM5A (0.40) | DYRK1AWNT1PIM1 | |
| SCHEMBL5873012 | 0.82 | KDM5A (0.41) | DYRK1APIM1ADORA2A | |
| SCHEMBL5872896 | 0.82 | HRH3 (0.39) | DYRK1APIM1 | |
| SCHEMBL5873087 | 0.82 | KDM5A (0.39) | DYRK1APIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984652-B2 | Gyrase inhibitors | WARNER-LAMBERT COMPANY LLC (US) | 2006-01-10 | — | — | US | disclosed |
| US-20050250823-A1 | Gyrase inhibitors | YAGER KRAIG | 2005-11-10 | — | — | US | disclosed |
| US-20050054697-A1 | Gyrase inhibitors | PFIZER INC. | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054697-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | DYRK1A 1836/4885WNT1 3712/4885PIM1 1909/4885 |
| US-20050250823-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | DYRK1A 1836/4885WNT1 3712/4885PIM1 1909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.