Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 5/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872911 | 0.82 | MEN1 (0.42) | MAP2K1MEN1KMT2ATDP1MAP2K2 | |
| SCHEMBL5872755 | 0.81 | MEN1 (0.39) | MAP2K1MEN1KMT2ATDP1MAP2K2 | |
| SCHEMBL5872969 | 0.79 | MAP2K1 (0.40) | MAP2K1MEN1KMT2ATDP1MAP2K2 | |
| SCHEMBL5872786 | 0.77 | MEN1 (0.45) | MAP2K1MEN1KMT2ATDP1MAP2K2 | |
| SCHEMBL5873041 | 0.77 | ROCK2 (0.39) | MEN1KMT2ATDP1IDO1 | |
| SCHEMBL5872850 | 0.74 | MAP2K1 (0.56) | MAP2K1MEN1KMT2ATDP1MAP2K2 | |
| SCHEMBL5872765 | 0.74 | MAP2K1 (0.52) | MAP2K1MEN1KMT2ATDP1MAP2K2 | |
| SCHEMBL5872766 | 0.74 | MAP2K1 (0.52) | MAP2K1MEN1KMT2ATDP1MAP2K2 | |
| SCHEMBL5872791 | 0.73 | MAP2K1 (0.48) | MAP2K1MEN1KMT2ATDP1MAP2K2 | |
| SCHEMBL5872799 | 0.73 | MAP2K1 (0.49) | MAP2K1MEN1KMT2ATDP1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001905-B2 | Substituted diarylamines as MEK inhibitors | WARNER-LAMBERT COMPANY (US) | 2006-02-21 | — | — | US | disclosed |