Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 3/20 | 0.36 |
| ▸ | PLAUR | Q03405 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5873160 | 0.93 | CYP2C9 (0.42) | CYP3A4CYP2D6CYP2C9CYP2C19HTR2C | |
| SCHEMBL5773190 | 0.91 | HTR2C (0.45) | HTR2CPIM1PLAURPIK3CDHTT | |
| SCHEMBL5769465 | 0.91 | CYP3A4 (0.38) | CYP3A4CYP2D6CYP2C9CYP2C19PIM1 | |
| SCHEMBL5873046 | 0.88 | CYP2C9 (0.43) | CYP2C9HRH4PIM1KDM5AHCRTR1 | |
| SCHEMBL5772558 | 0.87 | ADORA2A (0.39) | PIM1HTTKDM5AHCRTR1HCRTR2 | |
| SCHEMBL5873018 | 0.86 | GRM4 (0.40) | CYP3A4CYP2D6CYP2C9CYP2C19PIM1 | |
| SCHEMBL5873211 | 0.86 | CYP2C9 (0.48) | CYP2C9HRH4PIM1KDM5A | |
| SCHEMBL5772393 | 0.86 | HCRTR1 (0.38) | PIM1HTTKDM5AHCRTR1HCRTR2 | |
| SCHEMBL5873053 | 0.86 | KDM5A (0.37) | PIM1HTTKDM5AHCRTR1HCRTR2 | |
| SCHEMBL5872873 | 0.85 | CYP2C9 (0.47) | CYP2C9PIM1KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984652-B2 | Gyrase inhibitors | WARNER-LAMBERT COMPANY LLC (US) | 2006-01-10 | — | — | US | disclosed |
| US-20050250823-A1 | Gyrase inhibitors | YAGER KRAIG | 2005-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050250823-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | CYP3A4 871/4885CYP2D6 605/4885CYP2C9 695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.