Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | CES1 | P23141 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.53 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30758864 | 0.94 | PARP1 (0.61) | MEN1KMT2ASMN1; SMN2MAPTCYP3A4 | |
| SCHEMBL1162756 | 0.89 | PARP1 (0.55) | MEN1KMT2ASMN1; SMN2MAPTCYP3A4 | |
| SCHEMBL5873147 | 0.86 | KMT2A (0.68) | MEN1KMT2ASMN1; SMN2MAPTCYP3A4 | |
| SCHEMBL4834885 | 0.86 | MEN1 (0.81) | MEN1KMT2ASMN1; SMN2MAPTCYP3A4 | |
| SCHEMBL2822591 | 0.83 | L3MBTL1 (0.56) | MEN1KMT2ASMN1; SMN2MAPTCYP3A4 | |
| SCHEMBL751516 | 0.82 | HPGD (0.74) | MEN1KMT2ASMN1; SMN2MAPTCYP3A4 | |
| SCHEMBL931177 | 0.81 | MAPT (0.57) | MEN1KMT2ASMN1; SMN2MAPTKDM4E | |
| Dibenzoylmethane SCHEMBL39582 | 0.81 | MEN1 (1.00) | MEN1KMT2ASMN1; SMN2MAPTCYP3A4 | |
| Dibenzoylmethane SCHEMBL10356288 | 0.81 | MEN1 (1.00) | MEN1KMT2ASMN1; SMN2MAPTCYP3A4 | |
| Dibenzoylmethane SCHEMBL1704711 | 0.81 | MEN1 (1.00) | MEN1KMT2ASMN1; SMN2MAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105503945-A | Method for preparing 2-phosphonic acid ester base-1, 3-dicarbonyl derivative | UNIV SOOCHOW | 2016-04-20 | — | — | CN | claimed |
| US-7067702-B2 | Process for preparing vinyl substituted beta-diketones | THE JOHNS HOPKINS UNIVERSITY (US) | 2006-06-27 | — | — | US | claimed |
| US-20060069288-A1 | Process for preparing vinyl substituted beta-diketones | THE JOHNS HOPKINS UNIVERSITY | 2006-03-30 | — | — | US | claimed |
| CN-105503945-B | A kind of method for preparing the Dicarbonyl derivatives of 2 phosphonate group 1,3 | 苏州大学 | 2017-09-05 | — | — | CN | disclosed |
| CN-105503945-A | Method for preparing 2-phosphonic acid ester base-1, 3-dicarbonyl derivative | UNIV SOOCHOW | 2016-04-20 | — | — | CN | disclosed |
| US-7067702-B2 | Process for preparing vinyl substituted beta-diketones | THE JOHNS HOPKINS UNIVERSITY (US) | 2006-06-27 | — | — | US | disclosed |
| US-20060069288-A1 | Process for preparing vinyl substituted beta-diketones | THE JOHNS HOPKINS UNIVERSITY | 2006-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069288-A1 | Process for preparing vinyl substituted beta-diketones | VRK1, VRK2, DEK | MEN1 2957/4885KMT2A 1338/4885SMN1; SMN2 4225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.