Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 13/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5873497 | 1.00 | MCHR1 (0.52) | MCHR1KCNH2PDE10AMAPTMAP4K4 | |
| SCHEMBL5873725 | 0.82 | MCHR1 (0.55) | MCHR1KCNH2MAPT | |
| SCHEMBL5873730 | 0.82 | MCHR1 (0.55) | MCHR1KCNH2MAPT | |
| SCHEMBL6557630 | 0.81 | MCHR1 (0.53) | MCHR1KCNH2MAPT | |
| SCHEMBL5873574 | 0.78 | MAP4K4 (0.61) | MCHR1PDE10AMAP4K4SUV39H2 | |
| Hydrochloric Acid SCHEMBL5873477 | 0.77 | MAPT (0.62) | MCHR1MAPT | |
| SCHEMBL22499904 | 0.77 | PDE10A (0.58) | MCHR1PDE10AMAP4K4SUV39H2 | |
| SCHEMBL29689781 | 0.77 | PDE10A (0.58) | MCHR1PDE10AMAP4K4SUV39H2 | |
| Hydrochloric Acid SCHEMBL5873480 | 0.77 | MAPT (0.62) | MCHR1MAPT | |
| SCHEMBL24166014 | 0.77 | MAP4K4 (0.59) | PDE10AMAP4K4SUV39H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7084156-B2 | 2-Aminoquinoline compounds | MERCK & CO., INC. (US) | 2006-08-01 | — | — | US | claimed |
| US-20050026915-A1 | 2-Aminoquinoline compounds | MERCK SHARP & DOHME CORP. | 2005-02-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026915-A1 | 2-Aminoquinoline compounds | MCHR1, MCHR2, MC5R | MCHR1 1/4885KCNH2 3741/4885PDE10A 1245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.