Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 1,3-Butanediol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 2/20 | 0.40 |
| ▸ | GABRD | O14764 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.40 |
| ▸ | GABRE | P78334 | 2/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.40 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.40 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.40 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1,3-Butanediol SCHEMBL29094771 | 0.92 | TDP1 (0.40) | TDP1ALDH1A1GABRPGABRDGABRA1 | |
| 1,3-Butanediol SCHEMBL9486917 | 0.92 | TDP1 (0.40) | TDP1ALDH1A1GABRPGABRDGABRA1 | |
| 1,3-Butanediol SCHEMBL2195943 | 0.92 | TDP1 (0.40) | TDP1ALDH1A1GABRPGABRDGABRA1 | |
| 1,3-Butanediol SCHEMBL27552678 | 0.92 | TDP1 (0.40) | TDP1ALDH1A1GABRPGABRDGABRA1 | |
| Lactic Acid SCHEMBL10632947 | 0.89 | TP53 (0.58) | TDP1ALDH1A1GABRPGABRDGABRA1 | |
| 1,3-Butanediol SCHEMBL11041309 | 0.89 | TP53 (0.43) | TDP1ALDH1A1GABRPGABRDGABRA1 | |
| 1,3-Butanediol SCHEMBL27943842 | 0.88 | TDP1 (0.42) | TDP1ALDH1A1GABRPGABRDGABRA1 | |
| 1,3-Butanediol SCHEMBL3376246 | 0.88 | ALDH1A1 (0.34) | TDP1ALDH1A1GABRPGABRDGABRA1 | |
| 1,3-Butanediol SCHEMBL222874 | 0.87 | — | — | |
| 1,3-Butanediol SCHEMBL3427715 | 0.87 | TDP1 (0.53) | TDP1ALDH1A1TSHRTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 166 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635620-B1 | METHOD FOR PRODUCING POLYCARBONATE POLYOLS BY THE IMMORTAL POLYMERIZATION OF CYCLIC CARBONATES | COVESTRO DEUTSCHLAND AG (DE) | 2016-06-08 | — | — | EP | claimed |
| US-9260562-B2 | Method for producing polycarbonate polyols by the immortal polymerization of cyclic carbonates | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-02-16 | — | — | US | claimed |
| US-20140018517-A1 | METHOD FOR PRODUCING POLYCARBONATE POLYOLS BY THE IMMORTAL POLYMERIZATION OF CYCLIC CARBONATES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-01-16 | — | — | US | claimed |
| US-7049387-B2 | Cure accelerator system for phenolic resins | GEORGIA-PACIFIC RESINS, INC. (US) | 2006-05-23 | — | — | US | claimed |
| US-20030071393-A1 | Cure accelerator system for phenolic resins | JPMORGAN CHASE BANK, N.A. | 2003-04-17 | — | — | US | claimed |
| EP-1302489-A1 | Cure accelerator system for phenolic resins | GEORGIA-PACIFIC CORPORATION (US) | 2003-04-16 | — | — | EP | claimed |
| EP-0469785-B1 | Retarders for curing/hardening resole resins | BORDEN INC (US) | 1995-01-11 | — | — | EP | claimed |
| US-5096983-A | Magnesium oxide and and ester as hardeners, retarder to inhibit hardening | BORDEN, INC. (US) | 1992-03-17 | — | — | US | claimed |
| EP-0469785-A2 | Retarders for curing/hardening resole resins | Borden, Inc. (US) | 1992-02-05 | — | — | EP | claimed |
| EP-0050811-B1 | PROCESS FOR PREPARING ANIONIC COPOLYMERISATES FROM CYCLIC CARBONIC-ACID ESTERS AND LACTAMS, AND THEIR USE | BAYER AG (DE) | 1985-02-13 | — | — | EP | claimed |
| EP-4709778-A1 | PROCESSES FOR PREPARING A MIXTURE THAT CONTAINS A POLYOXYALKYLENE POLYOL | Covestro Deutschland AG (DE) | 2026-03-18 | — | — | EP | disclosed |
| US-12515174-B2 | Articles including an isoporous membrane disposed on a porous substrate and methods of making the same | SOLVENTUM INTELLECTUAL PROPERTIES COMPANY (US) | 2026-01-06 | — | — | US | disclosed |
| WO-2024231371-A1 | PROCESSES FOR PREPARING A MIXTURE THAT CONTAINS A POLYOXYALKYLENE POLYOL | COVESTRO DEUTSCHLAND AG (DE) | 2024-11-14 | — | — | WO | disclosed |
| EP-4461762-A1 | METHOD FOR PRODUCING A MIXTURE CONTAINING A POLYOXYALKYLENE POLYOL; MIXTURE AND COMPONENTS OBTAINED FROM THE METHOD | Covestro Deutschland AG (DE) | 2024-11-13 | — | — | EP | disclosed |
| US-12060454-B2 | Process for the continuous production of polyoxyalkylene polyols | COVESTRO INTELLECTUAL PROPERTY GMBH & CO. KG (DE) | 2024-08-13 | — | — | US | disclosed |
| EP-0336534-A1 | Compositions for foundry molding processes utilizing reclaimed sand | ACME RESIN CORPORATION (US) | 1989-10-11 | — | — | EP | disclosed |
| EP-0336533-A2 | Process to enhance the tensile strength of reclaimed sand bonded with ester cured alkaline phenolic resin | BORDEN, INC. (US) | 1989-10-11 | — | — | EP | disclosed |
| US-4862948-A | Phenolic resin adhesive pastes, assemblies prepared therefrom, and processes for preparing cast metal articles using these pastes | BORDEN, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0259042-A2 | Process for bonding lignocellulosic material | Borden, Inc. (US) | 1988-03-09 | — | — | EP | disclosed |
| US-4431795-A | Copolymers of cyclic carbonic acid esters and lactams and their production | BAYER AKTIENGESELLSCHAFT (DE) | 1984-02-14 | — | — | US | disclosed |