Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHAT | P28329 | 3/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5873693 | 1.00 | CHAT (0.46) | CHATMAOBNFE2L2CYP11B1CYP11B2 | |
| SCHEMBL716198 | 0.98 | CHAT (0.48) | CHATMAOBNFE2L2ALDH1A1LMNA | |
| SCHEMBL336379 | 0.98 | CHAT (0.48) | CHATMAOBNFE2L2ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL4035927 | 0.95 | CHAT (0.46) | CHATMAOBNFE2L2ALDH1A1LMNA | |
| Methyl Alcohol SCHEMBL9420305 | 0.94 | CHAT (0.47) | CHATMAOBNFE2L2CYP11B1CYP11B2 | |
| SCHEMBL6406091 | 0.91 | CHAT (0.43) | CHATMAOBNFE2L2ALDH1A1LMNA | |
| SCHEMBL29260334 | 0.91 | CHAT (0.43) | CHATMAOBNFE2L2ALDH1A1LMNA | |
| Formaldehyde SCHEMBL8647913 | 0.91 | CHAT (0.43) | CHATMAOBNFE2L2ALDH1A1LMNA | |
| SCHEMBL6406093 | 0.91 | CHAT (0.43) | CHATMAOBNFE2L2ALDH1A1LMNA | |
| Formaldehyde SCHEMBL8647908 | 0.91 | CHAT (0.43) | CHATMAOBNFE2L2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-6289613-A | — | — | None | — | — | JP | disclosed |
| EP-1450860-B1 | ANIMAL FEEDS INCLUDING ACTIVES | RUBICON SCIENT LLC (US) | 2013-09-18 | — | — | EP | disclosed |
| US-20060121095-A1 | Animal feeds including actives and methods of preparing same | HUBER GORDON R | 2006-06-08 | — | — | US | disclosed |
| US-7052712-B2 | Animal feeds including actives and methods of preparing same | RUBICON SCIENTIFIC LLC (US) | 2006-05-30 | — | — | US | disclosed |
| EP-1450860-A4 | ANIMAL FEEDS INCLUDING ACTIVES AND METHODS OF USING SAME | RUBICON SCIENT LLC (US) | 2005-09-14 | — | — | EP | disclosed |
| US-20040234580-A1 | Animal feeds including actives and methods of using the same | RUBICON SCIENTIFIC LLC | 2004-11-25 | — | — | US | disclosed |
| EP-1450860-A2 | ANIMAL FEEDS INCLUDING ACTIVES AND METHODS OF USING SAME | Rubicon Scientific LLC (US) | 2004-09-01 | — | — | EP | disclosed |
| US-20030097992-A1 | Animal feeds including actives and methods of preparing same | RUBICON SCIENTIFIC LLC | 2003-05-29 | — | — | US | disclosed |
| WO-2003030653-A2 | ANIMAL FEEDS INCLUDING ACTIVES AND METHODS OF USING SAME | RUBICON SCIENTIFIC LLC (US) | 2003-04-17 | — | — | WO | disclosed |
| JP-H06289613-A | PHOTOSENSITIVE RESIN COMPOSITION FOR FORMATION OF TRANSPARENT COLOR PICTURE IMAGE AND COLOR FILTER | OJI KAKO KK | 1994-10-18 | — | — | JP | disclosed |
| US-4442086-A | Diethylcarbamazine resinate and styrylpyridinium resinate-diethylcarbamazine resinate edible anthelmintic tablets for companion animals | AMERICAN CYANAMID COMPANY (US) | 1984-04-10 | — | — | US | disclosed |
| US-4352891-A | ION EXCHANGING | AMERICAN CYANAMID CO. (US) | 1982-10-05 | — | — | US | disclosed |