Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.49 |
| ▸ | HTR3B | O95264 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.49 |
| ▸ | SUV39H2 | Q9H5I1 | 9/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5873574 | 0.85 | MAP4K4 (0.61) | PDE10AMAP4K4SUV39H2 | |
| SCHEMBL29689781 | 0.85 | PDE10A (0.58) | PDE10AMAP4K4SUV39H2 | |
| SCHEMBL22499904 | 0.85 | PDE10A (0.58) | PDE10AMAP4K4SUV39H2 | |
| SCHEMBL1091477 | 0.84 | MAPT (0.54) | PDE10AMAP4K4ALDH1A1SUV39H2LMNA | |
| SCHEMBL1091187 | 0.84 | MAPT (0.54) | PDE10AMAP4K4ALDH1A1SUV39H2LMNA | |
| SCHEMBL1091189 | 0.84 | MAPT (0.54) | PDE10AMAP4K4ALDH1A1SUV39H2LMNA | |
| SCHEMBL24166014 | 0.80 | MAP4K4 (0.59) | PDE10AMAP4K4SUV39H2 | |
| SCHEMBL2126251 | 0.80 | MAP4K4 (0.57) | PDE10AMAP4K4SUV39H2 | |
| SCHEMBL2143634 | 0.80 | MAP4K4 (0.57) | PDE10AMAP4K4SUV39H2 | |
| SCHEMBL29647987 | 0.80 | DRD2 (0.46) | PDE10AMAP4K4SUV39H2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7084156-B2 | 2-Aminoquinoline compounds | MERCK & CO., INC. (US) | 2006-08-01 | — | — | US | disclosed |
| US-20050026915-A1 | 2-Aminoquinoline compounds | MERCK SHARP & DOHME CORP. | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026915-A1 | 2-Aminoquinoline compounds | MCHR1, MCHR2, MC5R | PDE10A 1245/4885MAP4K4 1963/4885ALDH1A1 460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.