Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | TDP2 | O95551 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5873800 | 1.00 | RET (0.34) | RETTLK2JAK3AXLTDP2 | |
| SCHEMBL5873883 | 0.87 | CCNT1 (0.35) | RETJAK3AXLCCNT1CDK9 | |
| SCHEMBL5873886 | 0.87 | CCNT1 (0.35) | RETJAK3AXLCCNT1CDK9 | |
| SCHEMBL5873793 | 0.86 | JAK3 (0.39) | RETJAK3CCNT1CDK9MAP3K11 | |
| SCHEMBL5873796 | 0.86 | JAK3 (0.39) | RETJAK3CCNT1CDK9MAP3K11 | |
| SCHEMBL5873779 | 0.84 | RET (0.37) | RETTLK2JAK3AXLTDP2 | |
| SCHEMBL5873783 | 0.84 | RET (0.37) | RETTLK2JAK3AXLTDP2 | |
| SCHEMBL7726572 | 0.84 | AXL (0.32) | RETJAK3AXLMAP3K11CNR1 | |
| SCHEMBL5873876 | 0.82 | FLT1 (0.35) | RETTLK2JAK3AXLTDP2 | |
| SCHEMBL5873874 | 0.82 | FLT1 (0.35) | RETTLK2JAK3AXLTDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7129253-B2 | Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-31 | — | — | US | disclosed |
| US-6818632-B2 | 3-(anilinomethylene)oxindoles | SMITHKLINE BEECHAM CORPORATION | 2004-11-16 | — | — | US | disclosed |