Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 2/20 | 0.35 |
| ▸ | CDK9 | P50750 | 3/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | RET | P07949 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | GSK3A | P49840 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.35 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5873793 | 1.00 | JAK3 (0.39) | JAK3FDPSCDK9CCNT1NTRK1 | |
| SCHEMBL5873818 | 0.87 | CHEK2 (0.35) | JAK3CHEK1METIKBKETBK1 | |
| SCHEMBL5873832 | 0.87 | CHEK2 (0.35) | JAK3CHEK1METIKBKETBK1 | |
| SCHEMBL5873800 | 0.86 | RET (0.34) | JAK3CDK9CCNT1RETMAP3K11 | |
| SCHEMBL5873812 | 0.86 | RET (0.34) | JAK3CDK9CCNT1RETMAP3K11 | |
| SCHEMBL6872582 | 0.86 | CDK9 (0.40) | JAK3CDK9CCNT1NTRK1CHEK1 | |
| SCHEMBL6872584 | 0.86 | CDK9 (0.40) | JAK3CDK9CCNT1NTRK1CHEK1 | |
| SCHEMBL5873953 | 0.85 | NTRK1 (0.41) | FDPSCDK9CCNT1NTRK1FLT3 | |
| SCHEMBL5873956 | 0.85 | NTRK1 (0.41) | FDPSCDK9CCNT1NTRK1FLT3 | |
| SCHEMBL7728583 | 0.82 | JAK3 (0.36) | JAK3FDPSCDK9NTRK1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7129253-B2 | Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-31 | — | — | US | disclosed |
| US-6818632-B2 | 3-(anilinomethylene)oxindoles | SMITHKLINE BEECHAM CORPORATION | 2004-11-16 | — | — | US | disclosed |