Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | IDE | P14735 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5873873 | 1.00 | RAB9A (0.39) | RAB9AMAPTMEN1NPC1KMT2A | |
| SCHEMBL5873772 | 0.94 | RAB9A (0.43) | RAB9AMAPTMEN1NPC1KMT2A | |
| SCHEMBL5873767 | 0.94 | RAB9A (0.43) | RAB9AMAPTMEN1NPC1KMT2A | |
| SCHEMBL5873984 | 0.93 | AKR1C3 (0.40) | RAB9AALDH1A1TLK2GRIN2DGRIN3B | |
| SCHEMBL5873982 | 0.93 | AKR1C3 (0.40) | RAB9AALDH1A1TLK2GRIN2DGRIN3B | |
| SCHEMBL5430431 | 0.91 | ERBB2 (0.42) | RAB9AMAPTMEN1NPC1KMT2A | |
| SCHEMBL5873697 | 0.91 | ERBB2 (0.42) | RAB9AMAPTMEN1NPC1KMT2A | |
| SCHEMBL5430428 | 0.91 | ERBB2 (0.42) | RAB9AMAPTMEN1NPC1KMT2A | |
| SCHEMBL5182473 | 0.91 | PSEN1 (0.39) | RAB9AMAPTMEN1NPC1KMT2A | |
| SCHEMBL5182480 | 0.91 | PSEN1 (0.39) | RAB9AMAPTMEN1NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7129253-B2 | Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-31 | — | — | US | disclosed |
| US-6818632-B2 | 3-(anilinomethylene)oxindoles | SMITHKLINE BEECHAM CORPORATION | 2004-11-16 | — | — | US | disclosed |
| US-6498176-B1 | INHIBITING TUMOR GROWTH VIA INHIBITION OF TUMOR-RELATED ANGIOGENESIS | SMITHKLINEBEECHAM CORPORATION | 2002-12-24 | — | — | US | disclosed |
| US-6350747-B1 | PROTEIN SERINE/THREONINE KINASE AND PROTEIN TYROSINE KINASE ENZYME INHIBITORS; ANGIOGENESIS INHIBITORS; ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | GLAXO WELLCOME INC. | 2002-02-26 | — | — | US | disclosed |