Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.46 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.46 |
| ▸ | NEK7 | Q8TDX7 | 1/20 | 0.46 |
| ▸ | NEK6 | Q9HC98 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5873888 | 1.00 | TLK2 (0.46) | TLK2MAP3K11NEK7NEK6PIN1 | |
| SCHEMBL5873853 | 0.94 | TLK2 (0.50) | TLK2MAP3K11NEK7NEK6RAB9A | |
| SCHEMBL5873846 | 0.94 | TLK2 (0.50) | TLK2MAP3K11NEK7NEK6RAB9A | |
| SCHEMBL5873950 | 0.92 | MAP3K11 (0.42) | TLK2MAP3K11NEK7NEK6RAB9A | |
| SCHEMBL5873943 | 0.92 | MAP3K11 (0.42) | TLK2MAP3K11NEK7NEK6RAB9A | |
| SCHEMBL5893610 | 0.91 | TLK2 (0.44) | TLK2MAP3K11NEK7NEK6RAB9A | |
| SCHEMBL5893617 | 0.91 | TLK2 (0.44) | TLK2MAP3K11NEK7NEK6RAB9A | |
| SCHEMBL5873843 | 0.90 | MAP3K11 (0.48) | TLK2MAP3K11NEK7NEK6RAB9A | |
| SCHEMBL5873829 | 0.90 | MAP3K11 (0.48) | TLK2MAP3K11NEK7NEK6RAB9A | |
| SCHEMBL5425756 | 0.85 | TLK2 (0.48) | TLK2MAP3K11NEK7NEK6RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7129253-B2 | Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-31 | — | — | US | disclosed |
| US-6818632-B2 | 3-(anilinomethylene)oxindoles | SMITHKLINE BEECHAM CORPORATION | 2004-11-16 | — | — | US | disclosed |
| US-6498176-B1 | INHIBITING TUMOR GROWTH VIA INHIBITION OF TUMOR-RELATED ANGIOGENESIS | SMITHKLINEBEECHAM CORPORATION | 2002-12-24 | — | — | US | disclosed |