Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.42 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.42 |
| ▸ | NEK7 | Q8TDX7 | 1/20 | 0.42 |
| ▸ | NEK6 | Q9HC98 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 6/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5873943 | 1.00 | MAP3K11 (0.42) | MAP3K11TLK2NEK7NEK6AKR1C3 | |
| SCHEMBL5873884 | 0.92 | TLK2 (0.46) | MAP3K11TLK2NEK7NEK6CSNK2A1 | |
| SCHEMBL5873888 | 0.92 | TLK2 (0.46) | MAP3K11TLK2NEK7NEK6CSNK2A1 | |
| SCHEMBL5182734 | 0.92 | TLK2 (0.41) | MAP3K11TLK2NEK7NEK6P2RX3 | |
| SCHEMBL5182729 | 0.92 | TLK2 (0.41) | MAP3K11TLK2NEK7NEK6P2RX3 | |
| SCHEMBL5873829 | 0.90 | MAP3K11 (0.48) | MAP3K11TLK2NEK7NEK6ALDH1A1 | |
| SCHEMBL5873843 | 0.90 | MAP3K11 (0.48) | MAP3K11TLK2NEK7NEK6ALDH1A1 | |
| SCHEMBL5873846 | 0.86 | TLK2 (0.50) | MAP3K11TLK2NEK7NEK6CSNK2A1 | |
| SCHEMBL5873853 | 0.86 | TLK2 (0.50) | MAP3K11TLK2NEK7NEK6CSNK2A1 | |
| SCHEMBL5893617 | 0.85 | TLK2 (0.44) | MAP3K11TLK2NEK7NEK6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7129253-B2 | Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-31 | — | — | US | disclosed |
| US-6818632-B2 | 3-(anilinomethylene)oxindoles | SMITHKLINE BEECHAM CORPORATION | 2004-11-16 | — | — | US | disclosed |
| US-6498176-B1 | INHIBITING TUMOR GROWTH VIA INHIBITION OF TUMOR-RELATED ANGIOGENESIS | SMITHKLINEBEECHAM CORPORATION | 2002-12-24 | — | — | US | disclosed |
| US-6350747-B1 | PROTEIN SERINE/THREONINE KINASE AND PROTEIN TYROSINE KINASE ENZYME INHIBITORS; ANGIOGENESIS INHIBITORS; ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | GLAXO WELLCOME INC. | 2002-02-26 | — | — | US | disclosed |