Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.37 |
| ▸ | GSK3A | P49840 | 8/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.37 |
| ▸ | CDK1 | P06493 | 3/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.37 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2070779 | 0.73 | NEK2 (0.36) | GSK3BCDK5CDK5R1GSK3ACCNB2 | |
| SCHEMBL18289479 | 0.73 | AHR (0.50) | GSK3BCDK5CDK5R1CCNB2CDK1 | |
| SCHEMBL29697758 | 0.70 | GRIA1 (0.46) | LMNAPARP1 | |
| SCHEMBL5726226 | 0.68 | BRD4 (0.41) | LMNAPARP1 | |
| SCHEMBL17926391 | 0.66 | BRD4 (0.40) | LMNAPARP1 | |
| SCHEMBL1150222 | 0.63 | MAPT (0.42) | SRCAHRPDK2CMA1PDE3B | |
| SCHEMBL4150642 | 0.63 | MAPT (0.42) | SRCAHRPDK2CMA1PDE3B | |
| SCHEMBL23840126 | 0.63 | NOS3 (0.39) | LMNAPARP1 | |
| SCHEMBL7846846 | 0.63 | BRD4 (0.40) | LMNAPARP1 | |
| SCHEMBL6479921 | 0.63 | AHR (0.44) | GSK3BCDK5CDK5R1GSK3ACCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7129253-B2 | Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-31 | — | — | US | disclosed |
| US-6369086-B1 | Substituted oxidole derivatives as protein tyrosine and as protein serine/threonine kinase inhibitors | SMITHKLINE BEECHAM CORPORATION | 2002-04-09 | — | — | US | disclosed |