Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 4/20 | 0.33 |
| ▸ | TGM2 | P21980 | 3/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5419164 | 0.94 | CSF1R (0.39) | CHEK1AKT2MAP4K4CDK2IRAK4 | |
| SCHEMBL5419163 | 0.94 | CSF1R (0.39) | CHEK1AKT2MAP4K4CDK2IRAK4 | |
| SCHEMBL5419264 | 0.87 | TGM2 (0.34) | MAOAMAOBGSK3BCSF1RTGM2 | |
| SCHEMBL5419268 | 0.87 | TGM2 (0.34) | MAOAMAOBGSK3BCSF1RTGM2 | |
| SCHEMBL5873973 | 0.87 | TGM2 (0.34) | MAOAMAOBGSK3BCSF1RTGM2 | |
| SCHEMBL7704893 | 0.78 | TGM2 (0.47) | CHEK1CSF1RTGM2CDK1ALDH1A1 | |
| SCHEMBL7704891 | 0.78 | TGM2 (0.47) | CHEK1CSF1RTGM2CDK1ALDH1A1 | |
| SCHEMBL5428630 | 0.77 | LRRK2 (0.52) | GSK3BTGM2PDPK1KDM4E | |
| SCHEMBL5428629 | 0.77 | LRRK2 (0.52) | GSK3BTGM2PDPK1KDM4E | |
| SCHEMBL5468301 | 0.74 | PDGFRB (0.53) | CSF1RERBB2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7129253-B2 | Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-31 | — | — | US | disclosed |
| US-20040191210-A1 | Compounds | GLENNON KIMBERLEY CAROLINE (US) | 2004-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040191210-A1 | Compounds | CDK1, AKT1, RPS6KA1 | CHEK1 96/4885AKT2 28/4885MAOA 2011/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.