Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.38 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.36 |
| ▸ | TET3 | O43151 | 2/20 | 0.36 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 2/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | PGK1 | P00558 | 1/20 | 0.31 |
| ▸ | PGK2 | P07205 | 1/20 | 0.31 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL27714812 | 0.82 | SMN1; SMN2 (0.65) | SMN1; SMN2OR51E2TET2TET3TET1 | |
| Triethylene Glycol SCHEMBL30580745 | 0.80 | SMN1; SMN2 (0.62) | SMN1; SMN2OR51E2TET2TET3TET1 | |
| Triethylene Glycol SCHEMBL28065453 | 0.80 | SMN1; SMN2 (0.62) | SMN1; SMN2OR51E2TET2TET3TET1 | |
| Cadaverine Tartrate SCHEMBL5874856 | 0.79 | TSHR (0.46) | OR51E2 | |
| Malic Acid SCHEMBL27748793 | 0.79 | SMN1; SMN2 (0.83) | SMN1; SMN2OR51E2TET2TET3TET1 | |
| Malic Acid SCHEMBL28317492 | 0.79 | SMN1; SMN2 (0.83) | SMN1; SMN2OR51E2TET2TET3TET1 | |
| Lactic Acid SCHEMBL21219128 | 0.78 | TP53 (0.48) | OR51E2 | |
| Malic Acid SCHEMBL1835584 | 0.77 | SMN1; SMN2 (0.58) | SMN1; SMN2OR51E2TET2TET3TET1 | |
| Bicarbonate SCHEMBL2588842 | 0.76 | TSHR (0.35) | — | |
| Malic Acid SCHEMBL89131 | 0.76 | SMN1; SMN2 (1.00) | SMN1; SMN2OR51E2TET2TET3TET1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240138403-A1 | Synergistic Combinations for Reducing Volatility of Auxin Herbicides | ETHOX CHEMICALS, LLC | 2024-05-02 | — | — | US | claimed |
| US-20230021295-A1 | Synergistic Combinations for Reducing Volatility of Auxin Herbicides | ETHOX CHEMICALS, LLC | 2023-01-19 | — | — | US | claimed |
| WO-2023278670-A1 | SYNERGISTIC COMBINATIONS FOR REDUCING VOLATILITY OF AUXIN HERBICIDES | ETHOX CHEMICALS, LLC (US) | 2023-01-05 | — | — | WO | claimed |
| US-20240138403-A1 | Synergistic Combinations for Reducing Volatility of Auxin Herbicides | ETHOX CHEMICALS, LLC | 2024-05-02 | — | — | US | disclosed |
| US-20230021295-A1 | Synergistic Combinations for Reducing Volatility of Auxin Herbicides | ETHOX CHEMICALS, LLC | 2023-01-19 | — | — | US | disclosed |
| WO-2023278670-A1 | SYNERGISTIC COMBINATIONS FOR REDUCING VOLATILITY OF AUXIN HERBICIDES | ETHOX CHEMICALS, LLC (US) | 2023-01-05 | — | — | WO | disclosed |
| EP-3518878-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | Henkel AG & Co. KGaA (DE) | 2019-08-07 | — | — | EP | disclosed |
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |