Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propionic Acid SCHEMBL1071197 | 0.90 | FFAR3 (0.48) | THRBGPR84CHRM1AKR1A1CHRM3 | |
| SCHEMBL5990223 | 0.89 | — | — | |
| SCHEMBL5990222 | 0.89 | — | — | |
| SCHEMBL18718 | 0.89 | — | — | |
| SCHEMBL1478232 | 0.88 | THRB (0.40) | THRBGPR84CHRM1AKR1A1CHRM3 | |
| SCHEMBL6229980 | 0.88 | THRB (0.40) | THRBGPR84CHRM1AKR1A1CHRM3 | |
| Benzene SCHEMBL28083630 | 0.86 | THRB (0.48) | THRB | |
| Pivalate SCHEMBL15121418 | 0.86 | THRB (0.44) | THRBGPR84CHRM1AKR1A1CHRM3 | |
| Hydrochloric Acid SCHEMBL29959664 | 0.86 | — | — | |
| SCHEMBL28667805 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049387-B2 | Cure accelerator system for phenolic resins | GEORGIA-PACIFIC RESINS, INC. (US) | 2006-05-23 | — | — | US | claimed |
| US-20030071393-A1 | Cure accelerator system for phenolic resins | JPMORGAN CHASE BANK, N.A. | 2003-04-17 | — | — | US | claimed |
| EP-1302489-A1 | Cure accelerator system for phenolic resins | GEORGIA-PACIFIC CORPORATION (US) | 2003-04-16 | — | — | EP | claimed |
| EP-0469785-B1 | Retarders for curing/hardening resole resins | BORDEN INC (US) | 1995-01-11 | — | — | EP | claimed |
| US-5096983-A | Magnesium oxide and and ester as hardeners, retarder to inhibit hardening | BORDEN, INC. (US) | 1992-03-17 | — | — | US | claimed |
| EP-0469785-A2 | Retarders for curing/hardening resole resins | Borden, Inc. (US) | 1992-02-05 | — | — | EP | claimed |
| CN-112203750-B | Porous membranes comprising triblock copolymers | 3M创新有限公司（US） | 2023-01-13 | — | — | CN | disclosed |
| CN-113966360-A | Compositions comprising silylated polymers | 亨茨曼国际有限公司 | 2022-01-21 | — | — | CN | disclosed |
| US-10364323-B2 | Method for producing polyether carbonate polyols | COVESTRO DEUTSCHLAND AG (DE) | 2019-07-30 | — | — | US | disclosed |
| US-20180291148-A1 | METHOD FOR PRODUCING POLYETHER CARBONATE POLYOLS | COVESTRO DEUTSCHLAND AG (DE) | 2018-10-11 | — | — | US | disclosed |
| US-8865287-B2 | Rapid curing aldehyde resin-polyisocyanate composition and method for producing hybrid polymer | RAMBUS INC. | 2014-10-21 | — | — | US | disclosed |
| EP-2416907-A1 | ALKALINE PHENOLIC RESOLE RESIN COMPOSITIONS AND THEIR USE | Ashland Licensing and Intellectual Property LLC (US) | 2012-02-15 | — | — | EP | disclosed |
| EP-2352773-A1 | RAPID CURING ALDEHYDE RESIN-POLYISOCYANATE COMPOSITION AND METHOD FOR PRODUCING HYBRID POLYMER | Sylvanova, Inc. (US) | 2011-08-10 | — | — | EP | disclosed |
| EP-0469786-A2 | High surface area magnesia as hardener for phenolic resins | Borden, Inc. (US) | 1992-02-05 | — | — | EP | disclosed |
| EP-0469811-A2 | Accelerators for curing phenolic resole resins | Borden, Inc. (US) | 1992-02-05 | — | — | EP | disclosed |
| US-5043412-A | Blend of phenol-formaldehyde novolak and resole resins, and curing agent | BORDEN, INC. (US) | 1991-08-27 | — | — | US | disclosed |
| US-4961795-A | USING ALKALINE PHENOL-FORMALDEHYDE RESIN BINDER, CURING AGENT,AN MODIFIER | BORDEN, INC. (US) | 1990-10-09 | — | — | US | disclosed |
| EP-0336533-A2 | Process to enhance the tensile strength of reclaimed sand bonded with ester cured alkaline phenolic resin | BORDEN, INC. (US) | 1989-10-11 | — | — | EP | disclosed |
| US-4862948-A | Phenolic resin adhesive pastes, assemblies prepared therefrom, and processes for preparing cast metal articles using these pastes | BORDEN, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0259042-A2 | Process for bonding lignocellulosic material | Borden, Inc. (US) | 1988-03-09 | — | — | EP | disclosed |