Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL10607933 | 0.96 | HIF1A (0.46) | — | |
| Piperazine SCHEMBL28264572 | 0.96 | HIF1A (0.46) | — | |
| Piperazine SCHEMBL28301836 | 0.96 | HIF1A (0.46) | — | |
| Aziridine SCHEMBL27622900 | 0.96 | — | — | |
| Piperazine SCHEMBL28534942 | 0.87 | HIF1A (0.38) | — | |
| Pyrrolidine SCHEMBL702698 | 0.85 | — | — | |
| Azetidine SCHEMBL10008124 | 0.83 | — | — | |
| Piperidine SCHEMBL1627913 | 0.82 | — | — | |
| Azepane SCHEMBL31538612 | 0.82 | ALDH1A1 (0.60) | — | |
| Azetidine SCHEMBL28206632 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112321538-A | Method for synthesizing monoamine-protected piperazine- (R/S) 2-formate | 都创(上海)医药开发有限公司 | 2021-02-05 | — | — | CN | claimed |
| EP-3166981-B1 | OLIGOSACCHARIDE COMPOSITIONS AND METHODS FOR PRODUCING THEREOF | DSM NUTRITIONAL PRODUCTS LLC (US) | 2026-05-13 | — | — | EP | disclosed |
| US-12514267-B2 | Oligosaccharide compositions for use as animal feed and methods of producing thereof | DSM NUTRITIONAL PRODUCTS, LLC (US) | 2026-01-06 | — | — | US | disclosed |
| US-20250057202-A1 | OLIGOSACCHARIDE COMPOSITIONS FOR USE AS FOOD INGREDIENTS AND METHODS OF PRODUCING THEREOF | DSM NUTRITIONAL PRODUCTS LLC (US) | 2025-02-20 | — | — | US | disclosed |
| CN-117979966-A | Treatment of cancer using SOS1 inhibitors and RAS inhibitors | 锐新医药公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-117756751-A | Preparation method of 4- (4-hydroxyphenyl) -1-piperazine carboxylic acid ethyl ester | 宿迁晨阳医药科技有限公司 | 2024-03-26 | — | — | CN | disclosed |
| US-20230255240-A1 | OLIGOSACCHARIDE COMPOSITIONS FOR USE AS ANIMAL FEED AND METHODS OF PRODUCING THEREOF | MIDORI USA, INC. | 2023-08-17 | — | — | US | disclosed |
| EP-4205553-A1 | OLIGOSACCHARIDE COMPOSITIONS FOR USE ANIMAL FEED AND METHODS OF PRODUCING THEREOF | DSM Nutritional Products, LLC (US) | 2023-07-05 | — | — | EP | disclosed |
| CN-116209438-A | Treatment of malignant diseases with SHP2 mutations using SOS1 inhibitors | 锐新医药公司 | 2023-06-02 | — | — | CN | disclosed |
| US-11653676-B2 | Oligosaccharide compositions for use as animal feed and methods of producing thereof | DSM NUTRITIONAL PRODUCTS, LLC (US) | 2023-05-23 | — | — | US | disclosed |
| CN-106118595-A | A kind of method that quartz sand mine tailing prepares uv absorption powder body material | 安徽科技学院 | 2016-11-16 | — | — | CN | disclosed |
| WO-2016142819-A2 | NOVEL PROCESS FOR THE PREPARATION OF RANOLAZINE | UNICHEM LABORATORIES LIMITED (IN) | 2016-09-15 | — | — | WO | disclosed |
| CN-105932305-A | Oxygen Reduction Catalyst, Method For Producing The Same, And Polymer Electrolyte Fuel Cell | 昭和电工株式会社 | 2016-09-07 | — | — | CN | disclosed |
| CN-105907010-A | Method for preparing ultraviolet absorption thin-film material from quartz sand tailings powder | 安徽科技学院 | 2016-08-31 | — | — | CN | disclosed |
| CN-104812393-A | Tetrahydronaphthyridines and related bicyclic compounds for inhibition of ROR γ activity and treatment of disease | MERCK SHARP & DOHME | 2015-07-29 | — | — | CN | disclosed |
| CN-104311561-A | Preparation method of 7A-pyrrolizidine-acetonitrile | SUZHOU CANIMBLE BIOTECHNOLOGY CO LTD | 2015-01-28 | — | — | CN | disclosed |
| CN-104136431-A | PYRIDINONE AND PYRIMIDINONE DERIVATIVES AS FACTOR XIA INHIBITORS | ONO PHARMACEUTICAL CO | 2014-11-05 | — | — | CN | disclosed |
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| CN-1835926-A | Process for the preparation of nonpeptide substituded spirobenzoazepine derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2006-09-20 | — | — | CN | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |