Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | TACR1 | P25103 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3077113 | 0.93 | ALDH1A1 (0.38) | ALDH1A1THRBATML3MBTL1CHRM1 | |
| SCHEMBL579724 | 0.93 | ALDH1A1 (0.38) | ALDH1A1THRBATML3MBTL1CHRM1 | |
| SCHEMBL3085537 | 0.93 | ALDH1A1 (0.38) | ALDH1A1THRBATML3MBTL1CHRM1 | |
| SCHEMBL581649 | 0.81 | GAA (0.32) | ALDH1A1CHRM1GAA | |
| SCHEMBL582194 | 0.81 | GAA (0.32) | ALDH1A1CHRM1GAA | |
| SCHEMBL3078365 | 0.81 | GAA (0.32) | ALDH1A1CHRM1GAA | |
| SCHEMBL582112 | 0.79 | ALDH1A1 (0.39) | ALDH1A1THRBATML3MBTL1CHRM1 | |
| SCHEMBL581200 | 0.79 | HCRTR2 (0.36) | ALDH1A1THRBATML3MBTL1CHRM1 | |
| SCHEMBL581381 | 0.79 | HCRTR2 (0.36) | ALDH1A1THRBATML3MBTL1CHRM1 | |
| SCHEMBL586824 | 0.79 | HCRTR2 (0.36) | ALDH1A1THRBATML3MBTL1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |