Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 13/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 3/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3087720 | 0.92 | PLG (0.44) | PLGGABRA1GABRG2GABRB3MCHR1 | |
| SCHEMBL581701 | 0.92 | PLG (0.44) | PLGGABRA1GABRG2GABRB3MCHR1 | |
| SCHEMBL581218 | 0.92 | PLG (0.44) | PLGGABRA1GABRG2GABRB3MCHR1 | |
| SCHEMBL3069316 | 0.92 | PLG (0.44) | PLGGABRA1GABRG2GABRB3MCHR1 | |
| SCHEMBL588272 | 0.90 | PLG (0.42) | PLGGABRA1GABRG2GABRB3 | |
| SCHEMBL588011 | 0.89 | PLG (0.44) | PLGGABRA1GABRG2GABRB3 | |
| SCHEMBL580922 | 0.86 | PLG (0.42) | PLGGABRA1GABRG2GABRB3 | |
| SCHEMBL3796661 | 0.84 | PLG (0.40) | PLGGABRA1GABRG2GABRB3 | |
| SCHEMBL3079887 | 0.83 | PLG (0.45) | PLGGABRA1GABRG2GABRB3ENPP2 | |
| SCHEMBL586892 | 0.83 | PLG (0.45) | PLGGABRA1GABRG2GABRB3ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |