Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 13/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL588272 | 0.93 | PLG (0.42) | PLGGABRA1GABRG2GABRB3 | |
| SCHEMBL598012 | 0.92 | PLG (0.42) | PLGGABRA1GABRG2GABRB3KDM4E | |
| SCHEMBL3069533 | 0.92 | PLG (0.42) | PLGGABRA1GABRG2GABRB3KDM4E | |
| SCHEMBL580825 | 0.92 | PLG (0.42) | PLGGABRA1GABRG2GABRB3KDM4E | |
| SCHEMBL588248 | 0.92 | PLG (0.42) | PLGGABRA1GABRG2GABRB3KDM4E | |
| SCHEMBL587886 | 0.89 | PLG (0.43) | PLGGABRA1GABRG2GABRB3 | |
| SCHEMBL581798 | 0.87 | PLG (0.39) | PLGGABRA1GABRG2GABRB3 | |
| SCHEMBL587169 | 0.87 | PLG (0.39) | PLGGABRA1GABRG2GABRB3 | |
| SCHEMBL582098 | 0.86 | PLG (0.41) | PLGGABRA1GABRG2GABRB3TMEM97 | |
| SCHEMBL581153 | 0.84 | PLG (0.43) | PLGGABRA1GABRG2GABRB3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |