Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5924614 | 0.73 | ALDH1A1 (0.44) | KMT2AMEN1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL13369478 | 0.73 | TAAR1 (0.38) | KMT2AMEN1HPGDNPC1RAB9A | |
| SCHEMBL123057 | 0.72 | ALDH1A1 (0.54) | KMT2AMEN1HPGDNPC1RAB9A | |
| SCHEMBL28891561 | 0.71 | F2R (0.41) | KMT2AHPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL15979732 | 0.70 | ALDH1A1 (0.53) | KMT2AMEN1HPGDNPC1RAB9A | |
| SCHEMBL30089542 | 0.70 | ALDH1A1 (0.53) | KMT2AMEN1HPGDNPC1RAB9A | |
| SCHEMBL431985 | 0.69 | ALDH1A1 (0.38) | KMT2AHPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL17868849 | 0.68 | CYP3A4 (0.40) | KMT2AMEN1HPGDNPC1RAB9A | |
| SCHEMBL2962744 | 0.68 | TAAR1 (0.50) | KMT2AALDH1A1LMNA | |
| SCHEMBL875000 | 0.68 | NPC1 (0.47) | KMT2AMEN1HPGDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7034056-B2 | Aryl and biaryl compounds having MCH modulatory activity | PHARMACOPEIA DRUG DISCOVERY, INC. (US) | 2006-04-25 | — | — | US | disclosed |
| EP-1370520-A1 | ARYL AND BIARYL COMPOUNDS HAVING MCH MODULATORY ACTIVITY | PHARMACOPEIA, INC. (US) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002076929-A1 | ARYL AND BIARYL COMPOUNDS HAVING MCH MODULATORY ACTIVITY | PHARMACOPEIA, INC. (US) | 2002-10-03 | — | — | WO | disclosed |