Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 19/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 15/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 12/20 | 0.57 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5879364 | 0.89 | OPRD1 (0.62) | OPRD1OPRM1OPRK1PARP1 | |
| SCHEMBL5879355 | 0.87 | OPRD1 (0.57) | OPRD1OPRM1OPRK1PARP1 | |
| SCHEMBL5879387 | 0.86 | OPRD1 (0.59) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5879363 | 0.86 | OPRD1 (0.65) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5879321 | 0.85 | OPRD1 (0.76) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5879375 | 0.85 | OPRD1 (0.55) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5879342 | 0.85 | OPRD1 (0.57) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5879394 | 0.84 | OPRD1 (0.57) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5488273 | 0.84 | OPRD1 (0.72) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5879369 | 0.84 | OPRD1 (0.62) | OPRD1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395558-B1 | 4-(PHENYL-(PIPERIDIN-4-YL)-AMINO)-BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN, ANXIETY OR GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2005-12-21 | — | — | EP | claimed |
| US-7064137-B2 | Analgesics; anxiolytic agents; gastrointestinal disorders | ASTRAZENECA AB (SE) | 2006-06-20 | — | — | US | disclosed |